Results 91 to 100 of about 76,307 (263)

Biodegradable and Recyclable Luminescent Mixed‐Matrix‐Membranes, Hydrogels, and Cryogels based on Nanoscale Metal‐Organic Frameworks and Biopolymers

Advanced Functional Materials, EarlyView.
The study presents biodegradable and recyclable mixed‐matrix membranes (MMMs), hydrogels, and cryogels using luminescent nanoscale metal‐organic frameworks (nMOFs) and biopolymers. These bio‐nMOF‐MMMs combine europium‐based nMOFs as probes for the status of the materials with the biopolymers agar and gelatine and present alternatives to conventional ...
Moritz Maxeiner, Julian Burkhart, Kateryna Borysova, Chiara Mazzariol, Klaus Müller‐Buschbaum   +4 more
wiley   +1 more source

Dual‐Nanoparticle Engineered Hydrogel Reverses Bicellular Oxidative Stress to Accelerate Diabetic Fracture Healing

Advanced Functional Materials, EarlyView.
CD105‐LNPs and PS‐LNPs can deliver α‐lipoic acid to bone marrow mesenchymal stem cells and bone marrow‐derived macrophages, reversing high glucose‐induced oxidative stress while enhancing osteogenesis and M2 polarization. Integrating both nanoparticles into glucose‐responsive hyaluronic acid hydrogel forms DLNPs@HA hydrogel, which accelerates diabetic ...
Yanzhi Zhao, Weixian Hu, Shengming Zhang, Yuheng Liao, Kangkang Zha, Chenyan Yu, Zhenhe Zhang, Wenqian Zhang, Bobin Mi, Faqi Cao, Guohui Liu, Wu Zhou   +11 more
wiley   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Comprehensive characterization of natural products of Polygonum multiflorum by cheminformatics analysis

Pharmacological Research - Modern Chinese Medicine, 2023
Introduction: A growing body of evidence has suggested that Polygonum multiflorum Thunb. (PM) may cause PM-herb-induced liver injury (PM-HILI). However, the compounds triggering PM-HILI remain controversial.
Xiaowen Hu, Tingting Du, Zhao Wang, Feng Wei, Hua Chen, Shuangcheng Ma   +5 more
doaj  

Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury

Protein & Cell, 2017
Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive.
Yuewen Tang, Lin Cheng
doaj   +1 more source

Aptamer Functionalized Hydrogel Dressings for Post‐Surgery Tumor Recurrence Inhibition and Tissue Reconstruction

Advanced Functional Materials, EarlyView.
Post‐surgical tumor therapy struggles with recurrence and inefficient healing. Anti‐tumor DNA aptamer functionalized gelatin hydrogels, Apt‐GelMA, simultaneously address both issues by suppressing tumor regrowth via targeted tumor cell inhibition and enhancing wound healing through improved cell adhesion and migration. Their biocompatibility, stability,
Tianyue Li, Xin‐Yi Qian, Zi‐Yuan Li, Hao‐Wen Li, Poh‐Ching Tan, Chenghuizi Hu, Jiajun Jin, Shuang‐Bai Zhou, Qing‐Feng Li, He Tian, Junji Zhang, Itamar Willner   +11 more
wiley   +1 more source

Antioxidant and hepatoprotective effect of Jatropha dioica against the valproic acid-induced damage in an in vivo model

BMC Complementary Medicine and Therapies
Background Understanding liver diseases is important worldwide due to their prevalence. Apart from liver disease arising from hepatitis C viral infection, most chronic liver diseases currently have no cure.
Paula Cordero-Pérez, Ramiro Tijerina-Márquez, Veronica Mayela Rivas-Galindo, Liliana Torres-González, Diana Raquel Rodríguez-Rodríguez, Oscar Humberto Mendoza-Hernández, César Bigran Espinosa-Cantú, Guadalupe Yazmín Solís-Cruz, Linda E. Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Idalia Cura-Esquivel, Gabriela Alarcón-Galván, Diana Patricia Moreno-Pena   +12 more
doaj   +1 more source

Charakterisierung der Chemikalien-induzierten Leberschädigung („Drug-Induced Liver Injury“ – DILI)

, 2017
The aim of the presented PhD thesis was the development of a new in vitro test system which allows for a better characterization and prediction of drug- induced liver injuries (DILI). After the initial damage of hepatocytes, the activation of the immune system can aggravate this damage and lead to severe liver failure. This important interaction should
openaire   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state

Scientific Reports
Chronic liver injury induces fibrosis that often proceeds to cirrhosis and hepatocellular carcinoma, indicating that prevention and/or resolution of fibrosis is a promising therapeutic target.
Yasuhiro Nakano, Eiko Saijou, Tohru Itoh, Minoru Tanaka, Atsushi Miyajima, Taketomo Kido   +5 more
doaj   +1 more source