Clinical management of patients with drug-induced liver injury (DILI). [PDF]
United European Gastroenterol J, 2021 AbstractDrug‐induced liver injury (DILI) should be considered in all patients with recent elevation of liver tests without obvious etiology and normal hepatobiliary imaging. There is currently no biomarker that is helpful in diagnosis which relies on clinical and laboratory findings.
Björnsson ES.
europepmc +5 more sources
Biomarkers of idiosyncratic drug-induced liver injury (DILI) - a systematic review. [PDF]
Expert Opin Drug Metab Toxicol, 2021 Introduction: Idiosyncratic drug-induced liver injury (DILI) is an unpredictable event, and there are no specific biomarkers that can distinguish DILI from alternative explanations or predict its clinical outcomes. Areas covered: This systematic review summarizes the available evidence for all biomarkers proposed to have a role in the diagnosis or ...
Atallah E +6 more
europepmc +9 more sources
Metabolomic analysis to discriminate drug-induced liver injury (DILI) phenotypes. [PDF]
Arch Toxicol, 2021 AbstractDrug-induced liver injury (DILI) is an adverse toxic hepatic clinical reaction associated to the administration of a drug that can occur both at early clinical stages of drug development, as well after normal clinical usage of approved drugs. Because of its unpredictability and clinical relevance, it is of medical concern. Three DILI phenotypes
Quintás G +5 more
europepmc +7 more sources
Comparing Machine Learning Algorithms for Predicting Drug-Induced Liver Injury (DILI). [PDF]
Mol Pharm, 2020 Drug-induced liver injury (DILI) is one the most unpredictable adverse reactions to xenobiotics in humans and the leading cause of postmarketing withdrawals of approved drugs. To date, these drugs have been collated by the FDA to form the DILIRank database, which classifies DILI severity and potential.
Minerali E +4 more
europepmc +5 more sources
Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives. [PDF]
Curr Drug Metab, 2018 Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases.A structured search of bibliographic databases - Web of Science Core Collection, Scopus and Medline for peer-reviewed articles on models of DILI was performed.
Kuna L +8 more
europepmc +5 more sources
Oxidative Stress in Drug-Induced Liver Injury (DILI): From Mechanisms to Biomarkers for Use in Clinical Practice. [PDF]
Antioxidants (Basel), 2021 Villanueva-Paz M +6 more
europepmc +2 more sources
Idiosyncratic Drug-Induced Liver Injury (DILI) and Herb-Induced Liver Injury (HILI): Diagnostic Algorithm Based on the Quantitative Roussel Uclaf Causality Assessment Method (RUCAM). [PDF]
Diagnostics (Basel), 2021 Teschke R, Danan G.
europepmc +2 more sources
Drug-Induced Liver Injury in Tuberculosis: Mechanisms of Development and Diagnostic Methods
Juvenis Scientia, 2023 The review article discusses modern aspects of drug-induced liver injury (DILI) in patients with tuberculosis who are receiving etiotropic therapy. The main mechanisms of DILI, including toxic and idiosyncratic types, are described, as well as their ...
D. S. Sukhanov +3 more
doaj +1 more source
Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Apart from cessation of the implicated agent leading to drug-induced liver injury (DILI), there is no standard therapy for DILI. Corticosteroids have been used in DILI, although their efficacy is unclear.
Einar S. Björnsson +4 more
doaj +1 more source
Nature Communications, 2023 Diagnosis of rare, unpredictable, drug-induced liver injury (DILI) is a significant challenge for patients, clinicians, and drug development. Here, the authors discover, evaluate, and validate potential blood biomarkers to diagnose DILI and distinguish ...
Kodihalli C. Ravindra +27 more
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