Results 21 to 30 of about 6,710,280 (212)

Case of cholestatic drug-induced liver injury (DILI) associated with black cohosh. [PDF]

BMJ Case Rep, 2021
Drug-induced liver injury is an uncommon yet fatal cause of liver injury. Black cohosh is a herbal supplement that is derived from Actaea racemosa. It has been used for vasomotor symptoms in postmenopausal women, but it can cause liver injury. A 50-year-old Afro-American woman presented with a 2-month history of malaise, itching and severe jaundice ...
Brar HS, Marathi R.
europepmc   +3 more sources

Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure. [PDF]

Biol Direct, 2021
Abstract Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed.
Liu A, Walter M, Wright P, Bartosik A, Dolciami D, Elbasir A, Yang H, Bender A.   +7 more
europepmc   +8 more sources

Drug-Induced Liver Injury: A Literature Review [PDF]

, 2022
Drug-Induced liver injury (DILI) is a common harmful drug reaction of some medication which can cause the damage to liver cells, or might be a chance of death. In the western countries DILI is the main cause for acute liver failure.
Singh, Amar Pal, Malhotra, Meenakshi, Tandon, Pooja, Singh, Ajeet Pal, Melkani, Indu   +4 more
core   +1 more source

Comparing Machine Learning Algorithms for Predicting Drug-Induced Liver Injury (DILI). [PDF]

Mol Pharm, 2020
Drug-induced liver injury (DILI) is one the most unpredictable adverse reactions to xenobiotics in humans and the leading cause of postmarketing withdrawals of approved drugs. To date, these drugs have been collated by the FDA to form the DILIRank database, which classifies DILI severity and potential.
Minerali E, Foil DH, Zorn KM, Lane TR, Ekins S.   +4 more
europepmc   +4 more sources

A new framework for advancing in drug-induced liver injury research. The Prospective European DILI Registry [PDF]

, 2022
Background & Aims: No multi-national prospective study of drug-induced liver injury (DILI) has originated in Europe. The design of a prospective European DILI registry, clinical features and short-term outcomes of the cases and controls is reported ...
Alvarez‐Alvarez, Ismael, Cortez-Pinto, Helena, Robles-Díaz, María Mercedes, Björnsson, Einar S, Guido Stirnimann, Gerbes, Alexander L, Helena Cortez‐Pinto, Guruprasad P. Aithal, Alvarez-Alvarez, Ismael, Stirnimann, Guido, Andrade, Raul J., Stephens, Camilla, Grove, Jane I, Gerd Kullak‐Ublick, Kullak-Ublick, Gerd A, Andrade-Bellido, Raúl Jesús, Jane I. Grove, M. Isabel Lucena, Kullak-Ublick, Gerd, Robles-Diaz, Mercedes, Lucena-González, María Isabel, Lucena, M. Isabel, Raul J. Andrade, Kullak‐Ublick, Gerd, Grove, Jane I., Edmond Atallah, Aithal, Guruprasad P, Aithal, Guruprasad P., Andrade, Raul J, Alexander Gerbes, Gerbes, Alexander, Camilla Stephens, Einar S. Björnsson, Atallah, Edmond, Robles‐Diaz, Mercedes, Sabine Weber, Lucena, M Isabel, Weber, Sabine, Ismael Alvarez‐Alvarez, Björnsson, Einar S., Mercedes Robles‐Diaz, Cortez‐Pinto, Helena; https://orcid.org/, Atallah, Edmond; https://orcid.org/, Aithal, Guruprasad P; https://orcid.org/, Alvarez-Alvarez, Ismael; https://orcid.org/, Robles-Diaz, Mercedes; https://orcid.org/, Weber, Sabine; https://orcid.org/, Stirnimann, Guido; https://orcid.org/, Lucena, M Isabel; https://orcid.org/, Gerbes, Alexander; https://orcid.org/, Kullak-Ublick, Gerd; https://orcid.org/, Björnsson, Einar S; https://orcid.org/, Andrade, Raul J; https://orcid.org/, Grove, Jane I; https://orcid.org/   +53 more
core   +4 more sources

Computational Approaches for Drug-Induced Liver Injury (DILI) Prediction: State of the Art and Challenges [PDF]

, 2021
Drug-induced liver injury (DILI) is one of the prevailing causes of fulminant hepatic failure. It is estimated that three idiosyncratic drug reactions out of four result in liver transplantation or death. Additionally, DILI is the most common reason for withdrawal of an approved drug from the market.
Béquignon, O.J.M., Pawara, G., Water, B. van de, Cronin, M.T.D., Westen, G.J.P. van   +4 more
openaire   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Genetic variations in drug-induced liver injury (DILI): resolving the puzzle [PDF]

Frontiers in Genetics, 2012
Despite stringent requirements for drug development imposed by regulatory agencies, drug-induced liver injury (DILI) is an increasing health problem and a significant cause for failure to approve drugs, market withdrawal of commercialized medications, and adoption of regulatory measures.
Stephens, Camilla, Lucena, M Isabel, Andrade, Raúl J   +2 more
openaire   +4 more sources

Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor

Frontiers in Pharmacology, 2022
Of the patients infected with coronavirus disease 2019 (COVID-19), approximately 14–53% developed liver injury resulting in poor outcomes. Drug-induced liver injury (DILI) is the primary cause of liver injury in COVID-19 patients.
Jingjing Huang, Zhaokang Zhang, Chenxia Hao, Chenxia Hao, Yuzhen Qiu, Ruoming Tan, Jialin Liu, Xiaoli Wang, Wanhua Yang, Hongping Qu   +9 more
doaj   +1 more source

Indigenous Herbal Drug (Tinospora Cordifolia) Induced Liver Injury: A Case Report [PDF]

Bengal Physician Journal
Drug-induced liver injury (DILI) is a condition characterized by acute or chronic liver damage following the use of hepatotoxic drugs. It can be classified based on clinical presentation (hepatocellular, cholestasis, or mixed), mechanism of ...
Sounak Kumar Roy, Muniruddin SK, Subham Mondal, Sandipan Mukherjee, Santa Subhra Chatterjee   +4 more
doaj   +1 more source