Results 31 to 40 of about 7,552 (172)

Pregnane X receptor in drug-induced liver injury: Friend or foe?

Liver Research, 2018
The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications [PDF]

Journal of Hepatology, 2018
A 21-year old woman was admitted to hospital with a two-week history of painless jaundice, fatigue and anorexia having previously been fit and well. One month prior to presentation, the patient had taken a five-day course of amoxicillin-clavulanic acid for an infected skin cyst.
Kaliyaperumal, Kalaiyarasi, Grove, Jane I., Delahay, Robin M., Griffiths, William. J.H., Duckworth, Adam, Aithal, Guruprasad P.   +5 more
openaire   +2 more sources

Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress

Cell Death and Disease, 2023
Drug-induced liver injury (DILI) is the leading cause of acute liver failure (ALF). Continuous and prolonged hepatic cellular oxidative stress and liver inflammatory stimuli are key signatures of DILI.
Tingting Luo, Suzhen Yang, Tianming Zhao, Hanlong Zhu, Chunyan Chen, Xiaoxiao Shi, Di Chen, Kai Wang, Kang Jiang, Dan Xu, Ming Cheng, Juan Li, Wenting Li, Weijun Xu, Lin Zhou, Mingzuo Jiang, Bing Xu   +16 more
doaj   +1 more source

Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury

Journal of Food Quality, 2021
Numerous prescribed drugs and herbal and dietary supplements have been reported to cause drug-induced acute liver injury, which is a frequent cause of acute liver failure (ALF).
Liangliang Yao, Muhammad Farrukh Nisar, Tingdong Yan, Chunpeng (Craig) Wan   +3 more
doaj   +1 more source

Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment

Annals of Hepatology, 2017
Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepa-totoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF ...
Sunil Taneja, Pramod Kumar, Sahaj Rathi, Ajay Duseja, Virendra Singh, Radha Krishan Dhiman, Yogesh Kumar Chawla   +6 more
doaj   +1 more source

Drug‐Induced Liver Injury in GI Practice

Hepatology Communications, 2020
Although drug‐induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States.
Naemat Sandhu, Victor Navarro
doaj   +1 more source

Bismuth subcitrate, metronidazole and tetracycline – a rare cause of drug-induced liver injury

European Journal of Case Reports in Internal Medicine, 2023
Drug-induced liver injury (DILI) is a liver condition caused by any drug or toxic substance. The spectrum of DILI manifestations can range from asymptomatic elevation of liver enzymes to acute liver failure.
Carina Silva, Susana Merim, Rita Sevivas, João Mota, Alexandra Leitão   +4 more
doaj   +1 more source

A Comprehensive Review on the Use of Herbal Dietary Supplements in the USA, Reasons for Their Use, and Review of Potential Hepatotoxicity

Livers, 2022
Herbal and dietary supplement (HDS) use has grown exponentially in the United States. Unfortunately, the incidence of HDS-related liver injury has proportionally increased.
Adnan Khan, Kashyap Chauhan, Heather Ross, Natalia Salinas Parra, John Magagna, Makala Wang, Patrick Zhu, Ryan Erwin, Dina Halegoua-DeMarzio   +8 more
doaj   +1 more source

Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

Acta Pharmaceutica Sinica B, 2021
Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic ...
Payal Rana, Michael D. Aleo, Xuerong Wen, Stephen Kogut   +3 more
doaj   +1 more source