Results 31 to 40 of about 6,710,280 (212)

Hepatic macrophages in drug-induced liver injury

Liver Research, 2019
Drug-induced liver injury (DILI) is a major public health concern. Intrinsic DILI, for example, acetaminophen overdose accounts for half of acute liver failure in the United States.
Zhao Shan, Cynthia Ju
doaj   +1 more source

Features of Autoimmune Hepatitis in Patients With Drug-induced Liver Injury [PDF]

, 2017
Drug-induced liver injury (DILI) has features similar to those of other liver diseases including autoimmune hepatitis (AIH). We aimed to characterize the clinical and autoimmune features of liver injury caused by nitrofurantoin, minocycline, methyldopa ...
Zhao, Zhen, Drug-Induced Liver Injury Network., Long, Nanye, Kleiner, David E., Hoofnagle, Jay H., Chalasani, Naga, Urban, Thomas J., Kosinski, Andrzej S., de Boer, Ynto S.   +8 more
core   +1 more source

Pregnane X receptor in drug-induced liver injury: Friend or foe?

Liver Research, 2018
The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj   +1 more source

An Overview on the Proposed Mechanisms of Antithyroid Drugs-Induced Liver Injury [PDF]

Advanced Pharmaceutical Bulletin, 2015
Drug-induced liver injury (DILI) is a major problem for pharmaceutical industry and drug development. Mechanisms of DILI are many and varied.
Reza Heidari, Hossein Niknahad, Akram Jamshidzadeh, Mohammad Ali Eghbal, Narges Abdoli   +4 more
doaj   +1 more source

Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications [PDF]

Journal of Hepatology, 2018
A 21-year old woman was admitted to hospital with a two-week history of painless jaundice, fatigue and anorexia having previously been fit and well. One month prior to presentation, the patient had taken a five-day course of amoxicillin-clavulanic acid for an infected skin cyst.
Kaliyaperumal, Kalaiyarasi, Grove, Jane I., Delahay, Robin M., Griffiths, William. J.H., Duckworth, Adam, Aithal, Guruprasad P.   +5 more
openaire   +2 more sources

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Hepatocyte DDX3X protects against drug-induced acute liver injury via controlling stress granule formation and oxidative stress

Cell Death and Disease, 2023
Drug-induced liver injury (DILI) is the leading cause of acute liver failure (ALF). Continuous and prolonged hepatic cellular oxidative stress and liver inflammatory stimuli are key signatures of DILI.
Tingting Luo, Suzhen Yang, Tianming Zhao, Hanlong Zhu, Chunyan Chen, Xiaoxiao Shi, Di Chen, Kai Wang, Kang Jiang, Dan Xu, Ming Cheng, Juan Li, Wenting Li, Weijun Xu, Lin Zhou, Mingzuo Jiang, Bing Xu   +16 more
doaj   +1 more source

Diagnosis of drug induced liver injury using a lymphocyte blast transformation test based on whole blood culture [PDF]

, 1977
Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture ...
Takata, Shinji
core   +1 more source

Potential Effects of Dietary Isoflavones on Drug-Induced Liver Injury

Journal of Food Quality, 2021
Numerous prescribed drugs and herbal and dietary supplements have been reported to cause drug-induced acute liver injury, which is a frequent cause of acute liver failure (ALF).
Liangliang Yao, Muhammad Farrukh Nisar, Tingdong Yan, Chunpeng (Craig) Wan   +3 more
doaj   +1 more source

Acute Liver Failure Due to Etodolac, a Selective Cycloxygenase- 2 (COX -2) Inhibitor Non-Steroidal Anti-Inflammatory Drug Established by RUCAM-Based Causality Assessment

Annals of Hepatology, 2017
Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepa-totoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF ...
Sunil Taneja, Pramod Kumar, Sahaj Rathi, Ajay Duseja, Virendra Singh, Radha Krishan Dhiman, Yogesh Kumar Chawla   +6 more
doaj   +1 more source