Results 41 to 50 of about 6,710,280 (212)

Drug‐Induced Liver Injury in GI Practice

Hepatology Communications, 2020
Although drug‐induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States.
Naemat Sandhu, Victor Navarro
doaj   +1 more source

Bismuth subcitrate, metronidazole and tetracycline – a rare cause of drug-induced liver injury

European Journal of Case Reports in Internal Medicine, 2023
Drug-induced liver injury (DILI) is a liver condition caused by any drug or toxic substance. The spectrum of DILI manifestations can range from asymptomatic elevation of liver enzymes to acute liver failure.
Carina Silva, Susana Merim, Rita Sevivas, João Mota, Alexandra Leitão   +4 more
doaj   +1 more source

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury [PDF]

, 2019
BACKGROUND & AIMS: We performed genetic analyses of a multiethnic cohort of patients with idiosyncratic drug-induced liver injury (DILI) to identify variants associated with susceptibility.
Int DILI Consortium iDILIC, Laitinen, Tarja, Cirulli, Elizabeth T., Nicoletti, Paola, Drug-Induced Liver Injury Network   +4 more
core   +1 more source

Artificial Intelligence-Based Techniques to Assess Drug Toxicity in Drug-Induced Liver Injury (DILI) Disease

, 2022
Artificial Intelligence-Based Techniques to Assess Drug Toxicity in Drug-Induced Liver Injury (DILI ...
M Puri (13326006)
core   +1 more source

Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury via mitochondrial or other mechanisms

Acta Pharmaceutica Sinica B, 2021
Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic ...
Payal Rana, Michael D. Aleo, Xuerong Wen, Stephen Kogut   +3 more
doaj   +1 more source

Advanced preclinical models for evaluation of drug induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [Pro-Euro-DILI-Net] [PDF]

, 2021
Drug induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the leading indications for liver transplantation in Western societies.
Fromenty, B., Sancho-Bru, Pau, Ye, H., Fromenty, Bernard, Cubero, F, Miranda, J., Fernandez-Checa, J. C., Elfick, A., Dejneka, A., Konu, O, Aithal, Guruprasad, P, McDonald, A, Fernandez-Checa, Jose C., Falcon-Perez, JM, Andrade, Raul J., Kranendonk, M, Lunov, O., Royo, Felix, McDonald, A., Cubero, Francisco Javier, McDonald, Alison, Kranendonk, M., Elfick, A, Sancho-Bru, P., Lucena, M. I., Andrade, R. J., Krannendonk, Michel, Nelson, Leonard J, Falcon-Perez, Juan M., Lucena, M. Isabel, Aithal, G. P., Cubero, F. J., Bagnaninchi, Pierre, Lucena, M Isabel, Sullivan, Gareth John, Bagnaninchi, Pierre; id_orcid, Sullivan, G. J., Aithal, Guruprasad,, Lucena, M Isabel, Isabel, Ye, H, Sullivan, Gareth J., Miranda, Joana P., Lunov, Oleg, Nelson, Leonard J., Kranendonk, Michel, Elfick, Alistair, Nelson, L. J., Falcon-Perez, J. M., Lucena, MI, Royo, F., Bagnaninchi, P., Bagnaninchi, Pierre-Olivier, Aithal, Guruprasad, Garcia-Ruiz, Carmen, Konu, Ozlen, Ye, Hui, Lucena, M Isabel,, Falcon-Perez, Juan M, Dejneka, Alexandr, Andrade, Raul J, Aithal, Guruprasad P., Fernandez-Checa, Jose C, Aithal, Guruprasad P, Garcia-Ruiz, C., Fromenty, B, Miranda, Joana, Sullivan, Gareth J, Isabel Lucena, M., Javier Cubero, Francisco, Sullivan, Gareth J; id_orcid, Oleg Lunov, Pierre Bagnaninchi, Hui Ye, Bernard Fromenty, Guruprasad P. Aithal, Gareth J. Sullivan, Jose C. Fernandez-Checa, Alistair Elfick, Leonard J. Nelson, Alison McDonald, Raul J. Andrade, Carmen Garcia-Ruiz, Ozlen Konu, Alexandr Dejneka, Felix Royo, Michel Kranendonk, Pau Sancho-Bru, Francisco Javier Cubero, Joana Miranda, M. Isabel Lucena, Juan M. Falcon-Perez   +90 more
core   +1 more source

A Comprehensive Review on the Use of Herbal Dietary Supplements in the USA, Reasons for Their Use, and Review of Potential Hepatotoxicity

Livers, 2022
Herbal and dietary supplement (HDS) use has grown exponentially in the United States. Unfortunately, the incidence of HDS-related liver injury has proportionally increased.
Adnan Khan, Kashyap Chauhan, Heather Ross, Natalia Salinas Parra, John Magagna, Makala Wang, Patrick Zhu, Ryan Erwin, Dina Halegoua-DeMarzio   +8 more
doaj   +1 more source

Value of liver biopsy in the diagnosis of drug-induced liver injury [PDF]

, 2022
Background & aims: The utility of liver biopsy in diagnosing or staging idiosyncratic drug-induced liver injury (DILI) is unclear. The aim of this study was to determine whether liver histology impacted causality assessment in suspected DILI using a ...
Ghabril, Marwan, Serrano, Jose, Bonacini, Maurizio, Odin, Joseph A., Kleiner, David E., Barnhart, Huiman X., Tillmann, Hans L., Rossi, Simona, Hayashi, Paul H., Ahmad, Jawad, Rockey, Don C., Drug-Induced Liver Injury Network, Maurizio Bonacini, Marwan Ghabril, Jose Serrano, Hans L. Tillmann, Paul H. Hayashi, Jawad Ahmad, Simona Rossi, Don C. Rockey, Joseph A. Odin, David E. Kleiner, Huiman X. Barnhart   +22 more
core   +1 more source

Clinical Characteristics of Patients with Drug-induced Liver Injury

Chinese Medical Journal, 2017
Background: Drug is an important cause of liver injury and accounts for up to 40% of instances of fulminant hepatic failure. Drug-induced liver injury (DILI) is increasing while the diagnosis becomes more difficult.
Li-Xia Yang, Cheng-Yuan Liu, Lun-Li Zhang, Ling-Ling Lai, Ming Fang, Chong Zhang   +5 more
doaj   +1 more source

Late-onset isavuconazole-induced liver injury

Medical Mycology Case Reports, 2018
Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking.
Felix Bongomin, Isabel Rodriguez-Goncer, Carol Lorden, Akaninyene Otu, Rohit Bazaz   +4 more
doaj   +1 more source