Results 51 to 60 of about 6,710,280 (212)

Managing the challenge of drug-induced liver injury a roadmap for the development and deployment of preclinical predictive models [PDF]

, 2019
International audienceDrug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model.
Ursula Klingmüller, Klingmüller, Ursula, Water, B. van de, Goldring, C.E., Philip G. Hewitt, Amy E. Chadwick, Michael J. Liguori, Chadwick, A.E., Blomme, Eric A, Ian M. Copple, Labbe, G., Dean J. Naisbitt, Snoeys, J., Paul Morgan, Naisbitt, D.J., Weaver, R.J., Jensen, K.G., Lovatt, C.A., Hewitt, Philip G, Guillouzo, A., Gerets, Helga H J, Helga H. J. Gerets, Pieters, Raymond H H, Jan Snoeys, Williams, Dominic P, Gilles Labbe, Copple, .IM., Liguori, Michael J, Bob van de Water, Klingmüller, U., Richard J. Weaver, Williams, D.P., Magnus Ingelman-Sundberg, Naisbitt, Dean J, Chadwick, Amy E, Park, B.K., Snoeys, Jan, Klingmueller, Ursula, Park, B Kevin, Pieters, Raymond HH, Pieters, R.H.H., Lovatt, Cerys A, Goldring, Christopher E, Juhila, Satu, Gerets, H.H.J., Morgan, Paul, Christopher E. Goldring, Dominic P. Williams, Blomme, E.A., Ingelman-Sundberg, M., Copple, Ian M, Guillouzo, André, Cerys A. Lovatt, Morgan, P., Eric A. Blomme, Jensen, Klaus Gjervig, Liguori, M.J., Satu Juhila, Labbe, Gilles, Klaus Gjervig Jensen, Gerets, Helga HJ, Juhila, S., Raymond H. H. Pieters, Hewitt, P.G., Ingelman-Sundberg, Magnus, Andre Guillouzo, B. Kevin Park, van de Water, Bob, Weaver, Richard J, Copple, IM, Gerets, HHJ, Weaver, RJ, Guillouzo, A, Jensen, KG, dIRAS RA-1, One Health Toxicologie, Chadwick, AE, Goldring, CE, Ingelman-Sundberg, M,, Blomme, EA, Hewitt, PG   +80 more
core   +1 more source

The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury

Frontiers in Pharmacology, 2021
Drug-induced liver injury (DILI) has become one of the major challenges of drug safety all over the word. So far, about 1,100 commonly used drugs including the medications used regularly, herbal and/or dietary supplements, have been reported to induce ...
Wenhui Liu, Wenhui Liu, Wenhui Liu, Wenhui Liu, Xiangchang Zeng, Xiangchang Zeng, Xiangchang Zeng, Xiangchang Zeng, Yating Liu, Yating Liu, Yating Liu, Yating Liu, Jinfeng Liu, Jinfeng Liu, Jinfeng Liu, Jinfeng Liu, Chaopeng Li, Lulu Chen, Hongying Chen, Hongying Chen, Hongying Chen, Hongying Chen, Dongsheng Ouyang, Dongsheng Ouyang, Dongsheng Ouyang, Dongsheng Ouyang, Dongsheng Ouyang   +26 more
doaj   +1 more source

Associations of gender and a proxy of female menopausal status with histological features of drug‐induced liver injury [PDF]

, 2017
BACKGROUND & AIM: Gender and menopause may contribute to type and severity of drug-induced liver injury (DILI) by influencing host responses to injury.
Gu, Jiezhun, Kleiner, David E., Fontana, Robert J., Tillmann, Hans L., Suzuki, Ayako, Drug‐induced Liver Injury Network, Bonkovsky, Herbert L., Barnhart, Huiman   +7 more
core   +1 more source

Liver Injury due to Intravenous Methylprednisolone in the Drug-Induced Liver Injury Network [PDF]

Background and AimsShort courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP-related DILI enrolled in the US DILI Network ...
Phillips, Elizabeth, Kleiner, David E., Fontana, Robert J., Hoofnagle, Jay H., Dellinger, Andrew, Chalasani, Naga, Barnhart, Huiman X., Li, Yi-Ju, Hayashi, Paul H., Ahmad, Jawad, Drug-Induced Liver Injury Network   +10 more
core   +1 more source

Causality assessment in drug-induced liver injury using a structured expert opinion process: Comparison to the Roussel-Uclaf causality assessment method [PDF]

, 2010
Drug-induced liver injury (DILI) is largely a diagnosis of exclusion and is therefore challenging. The US Drug-Induced Liver Injury Network (DILIN) prospective study used two methods to assess DILI causality: a structured expert opinion process and the ...
Seeff, Leonard B., Bonacini, Maurizio, US Drug-Induced Liver Injury Network, Freston, James, Fontana, Robert J., Chalasani, Naga, Fontana, Robert John, Freston, James W., Hayashi, Paul H., Rockey, Don C., Rochon, James   +10 more
core   +1 more source

A gene expression profile-based approach to screen the occurrence and predisposed host characteristics of drug-induced liver injury: a case study of Psoralea corylifolia Linn

Frontiers in Chemistry, 2023
Drug-induced liver injury (DILI) is one of the most common causes of a drug being withdrawn, and identifying the culprit drugs and the host factors at risk of causing DILI has become a current challenge. Recent studies have found that immune status plays
Ming-Liang Zhang, Ming-Liang Zhang, Ming-Liang Zhang, Ming-Liang Zhang, Wei-Xia Li, Wei-Xia Li, Wei-Xia Li, Wei-Xia Li, Xiao-Yan Wang, Xiao-Yan Wang, Xiao-Yan Wang, Xiao-Yan Wang, Hui Zhang, Hui Zhang, Hui Zhang, Hui Zhang, Ya-Li Wu, Ya-Li Wu, Ya-Li Wu, Ya-Li Wu, Liu-Qing Yang, Liu-Qing Yang, Liu-Qing Yang, Liu-Qing Yang, Xiao-Fei Chen, Xiao-Fei Chen, Xiao-Fei Chen, Xiao-Fei Chen, Shu-Qi Zhang, Shu-Qi Zhang, Shu-Qi Zhang, Shu-Qi Zhang, Yu-Long Chen, Ke-Ran Feng, Ke-Ran Feng, Ke-Ran Feng, Ke-Ran Feng, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang   +41 more
doaj   +1 more source

Liver Injury From Tumor Necrosis Factor-α Antagonists: Analysis of Thirty-four Cases [PDF]

, 2013
Tumor necrosis factor (TNF)-α antagonists have been associated with drug-induced liver injury (DILI).
Ghabril, Marwan, Davern, Tim, Serrano, Jose, Bonacini, Maurizio, US Drug-Induced Liver Injury Network, Kleiner, David E., Fontana, Robert J., Kum, Clarissa, Rochon, Jim, Bonkovsky, Herbert L., Hayashi, Paul H.   +10 more
core   +1 more source

Bacteroides fragilis 839 ameliorates anti-tuberculosis drugs-induced liver injury by suppressing inflammation and regulating gut microbiota in mice

Frontiers in Medicine
Anti-tuberculosis drug-induced liver injury (ATB-DILI), caused by first-line anti-tuberculosis (anti-TB) drugs, disrupts treatment and increases the risk of drug resistance.
Qiujuan Li, Chenbing Wu, Kangshuai Zhang, Ziyi Zhou, Jing Li, Jie Bai, Jun Cao, Xiaoxia Shi   +7 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Serum Hepatocyte Growth Factor Predicts Outcomes in Non-Acetaminophen Drug-Induced Acute Liver Failure. [PDF]

Liver Int
ABSTRACT Background and Aims Regenerative capacity and inflammatory responses are key determinants of outcome in acute liver failure (ALF). However, their prognostic significance in non‐acetaminophen drug‐induced liver injury with acute liver injury or ALF (non‐APAP‐DILI‐ALI/ALF) remains poorly defined.
Wang T, Bacot SM, Patterson K, Friedman D, Taylor C, Hong H, Liu J, Avigan MI, Hayashi P, Rule JA, Lee WM, Rakela J, Feldman GM, Chen M.   +13 more
europepmc   +2 more sources