Results 51 to 60 of about 12,590 (214)

Clinical Characteristics of Patients with Drug-induced Liver Injury

Chinese Medical Journal, 2017
Background: Drug is an important cause of liver injury and accounts for up to 40% of instances of fulminant hepatic failure. Drug-induced liver injury (DILI) is increasing while the diagnosis becomes more difficult.
Li-Xia Yang, Cheng-Yuan Liu, Lun-Li Zhang, Ling-Ling Lai, Ming Fang, Chong Zhang   +5 more
doaj   +1 more source

Liver safety assessment: required data elements and best practices for data collection and standardization in clinical trials. [PDF]

, 2014
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.A workshop was convened to discuss best practices
Andrade, Raul J, Avigan, Mark I, Bjornsson, Einar S, Cooper, Charles, Lewis, James H, Merz, Michael, Pasanen, Markku, Watkins, Paul B   +7 more
core   +2 more sources

Late-onset isavuconazole-induced liver injury

Medical Mycology Case Reports, 2018
Antifungal agents account for approximately 3% of Drug-Induced Liver Injury (DILI) cases. Isavuconazole is a novel triazole, and experience with long-term use of it is lacking.
Felix Bongomin, Isabel Rodriguez-Goncer, Carol Lorden, Akaninyene Otu, Rohit Bazaz   +4 more
doaj   +1 more source

Adverse drug reaction and organ damage: the liver [PDF]

, 2016
Drug-induced liver injury (Dili) is among the most challenging acute or chronic liver conditions to be handled by physicians. Despite its low incidence in the general population, Dili is a frequent cause of acute liver failure.
LICATA, Anna
core   +1 more source

The Immunological Mechanisms and Immune-Based Biomarkers of Drug-Induced Liver Injury

Frontiers in Pharmacology, 2021
Drug-induced liver injury (DILI) has become one of the major challenges of drug safety all over the word. So far, about 1,100 commonly used drugs including the medications used regularly, herbal and/or dietary supplements, have been reported to induce ...
Wenhui Liu, Wenhui Liu, Wenhui Liu, Wenhui Liu, Xiangchang Zeng, Xiangchang Zeng, Xiangchang Zeng, Xiangchang Zeng, Yating Liu, Yating Liu, Yating Liu, Yating Liu, Jinfeng Liu, Jinfeng Liu, Jinfeng Liu, Jinfeng Liu, Chaopeng Li, Lulu Chen, Hongying Chen, Hongying Chen, Hongying Chen, Hongying Chen, Dongsheng Ouyang, Dongsheng Ouyang, Dongsheng Ouyang, Dongsheng Ouyang, Dongsheng Ouyang   +26 more
doaj   +1 more source

A gene expression profile-based approach to screen the occurrence and predisposed host characteristics of drug-induced liver injury: a case study of Psoralea corylifolia Linn

Frontiers in Chemistry, 2023
Drug-induced liver injury (DILI) is one of the most common causes of a drug being withdrawn, and identifying the culprit drugs and the host factors at risk of causing DILI has become a current challenge. Recent studies have found that immune status plays
Ming-Liang Zhang, Ming-Liang Zhang, Ming-Liang Zhang, Ming-Liang Zhang, Wei-Xia Li, Wei-Xia Li, Wei-Xia Li, Wei-Xia Li, Xiao-Yan Wang, Xiao-Yan Wang, Xiao-Yan Wang, Xiao-Yan Wang, Hui Zhang, Hui Zhang, Hui Zhang, Hui Zhang, Ya-Li Wu, Ya-Li Wu, Ya-Li Wu, Ya-Li Wu, Liu-Qing Yang, Liu-Qing Yang, Liu-Qing Yang, Liu-Qing Yang, Xiao-Fei Chen, Xiao-Fei Chen, Xiao-Fei Chen, Xiao-Fei Chen, Shu-Qi Zhang, Shu-Qi Zhang, Shu-Qi Zhang, Shu-Qi Zhang, Yu-Long Chen, Ke-Ran Feng, Ke-Ran Feng, Ke-Ran Feng, Ke-Ran Feng, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang, Jin-Fa Tang   +41 more
doaj   +1 more source

Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury [PDF]

, 2015
Drug-induced liver injury (DILI) is a major concern for public health, as well as for drug development in the pharmaceutical industry, since it can cause liver failure and lead to drug withdrawal from the market and black box warnings.
Kim, Seung-Hyun, Naisbitt, Dean J
core   +1 more source

Bacteroides fragilis 839 ameliorates anti-tuberculosis drugs-induced liver injury by suppressing inflammation and regulating gut microbiota in mice

Frontiers in Medicine
Anti-tuberculosis drug-induced liver injury (ATB-DILI), caused by first-line anti-tuberculosis (anti-TB) drugs, disrupts treatment and increases the risk of drug resistance.
Qiujuan Li, Chenbing Wu, Kangshuai Zhang, Ziyi Zhou, Jing Li, Jie Bai, Jun Cao, Xiaoxia Shi   +7 more
doaj   +1 more source

Incidence of drug-induced liver injury in medical inpatients [PDF]

, 2018
Objectives: Drug-induced liver injury (DILI) is a common concern. However, data on DILI epidemiology in inpatients are sparse. Methods: To investigate the incidence of DILI, we screened all patients in the pharmacoepidemiological inpatient database ...
Cavallaro, Marzia, Fattinger, Karin, Folkers, Gerd, Meier, Peter, Meier, Yvonne, Pauli-Magnus, Christiane, Roos, Malgorzata   +6 more
core  

Death and Liver Transplantation within Two Years of Onset of Drug-Induced Liver Injury [PDF]

, 2017
Drug-induced liver injury (DILI) is an important cause of death and indication for liver transplantation (fatality). The role of DILI in these fatalities ispoorly characterized particularly when fatalities occur > 26 weeks after DILI onset.
Anania, Andrade, Bjornsson, Chalasani, Fontana, Fontana, Fontana, Fontana, Gustot, Jalan, Karvellas, Lee, Lee, Martinez, Medina-Caliz, Olson, Ostapowicz, Robles-Diaz, Rockey, Stickel, Stravitz, Zimmerman   +21 more
core   +2 more sources