A Rare Case of Drug-Induced Liver Injury (DILI) From Topiramate. [PDF]
CureusA 72-year-old male individual with a past medical history of seizures and ongoing management with topiramate for two months presented at the emergency department with jaundice. Ten days before the presentation, the patient started feeling fatigued and had intermittent generalized mild pain (grade 3/10) with dark-brown discoloration of urine.
Macasaet R +5 more
europepmc +3 more sources
Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues. [PDF]
Ann Transl Med, 2021 Clinical features of idiosyncratic drug induced liver injury (DILI) are well described in cases that have been assessed for causality using the Roussel Uclaf Causality Assessment Method (RUCAM), but our understanding of the mechanistic steps leading to injury is fragmentary.
Teschke R, Uetrecht J.
europepmc +4 more sources
Mortality associated with drug-induced liver injury (DILI). [PDF]
Transl Gastroenterol Hepatol, 2017 Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver failure and liver injury leading to transplantation, although in most cases self-remitting when administration of the offending drug is stopped (1-3). In rare cases DILI can lead to a persistent/chronic form of injury (4).
Björnsson ES, Björnsson HK.
europepmc +4 more sources
Case of cholestatic drug-induced liver injury (DILI) associated with black cohosh. [PDF]
BMJ Case Rep, 2021 Drug-induced liver injury is an uncommon yet fatal cause of liver injury. Black cohosh is a herbal supplement that is derived from Actaea racemosa. It has been used for vasomotor symptoms in postmenopausal women, but it can cause liver injury. A 50-year-old Afro-American woman presented with a 2-month history of malaise, itching and severe jaundice ...
Brar HS, Marathi R.
europepmc +3 more sources
Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure. [PDF]
Biol Direct, 2021 Abstract Background: Drug-induced liver injury (DILI) is a major safety concern characterized by a complex and diverse pathogenesis. In order to identify DILI early in drug development, a better understanding of the injury and models with better predictivity are urgently needed.
Liu A +7 more
europepmc +8 more sources
Comment: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment. [PDF]
Ann Pharmacother, 2021 Danjuma M +4 more
europepmc +4 more sources
Idiosyncratic Drug-Induced Liver Injury (DILI) and Herb-Induced Liver Injury (HILI): Diagnostic Algorithm Based on the Quantitative Roussel Uclaf Causality Assessment Method (RUCAM) [PDF]
Diagnostics, 2021 Rolf Teschke, Gaby Danan
exaly +2 more sources
Drug-Induced Liver Injury in Tuberculosis: Mechanisms of Development and Diagnostic Methods
Juvenis Scientia, 2023 The review article discusses modern aspects of drug-induced liver injury (DILI) in patients with tuberculosis who are receiving etiotropic therapy. The main mechanisms of DILI, including toxic and idiosyncratic types, are described, as well as their ...
D. S. Sukhanov +3 more
doaj +1 more source
Role of Corticosteroids in Drug-Induced Liver Injury. A Systematic Review
Frontiers in Pharmacology, 2022 Introduction: Apart from cessation of the implicated agent leading to drug-induced liver injury (DILI), there is no standard therapy for DILI. Corticosteroids have been used in DILI, although their efficacy is unclear.
Einar S. Björnsson +4 more
doaj +1 more source
Nature Communications, 2023 Diagnosis of rare, unpredictable, drug-induced liver injury (DILI) is a significant challenge for patients, clinicians, and drug development. Here, the authors discover, evaluate, and validate potential blood biomarkers to diagnose DILI and distinguish ...
Kodihalli C. Ravindra +27 more
doaj +1 more source