Results 11 to 20 of about 6,710,280 (212)

Models of Drug Induced Liver Injury (DILI) - Current Issues and Future Perspectives. [PDF]

Curr Drug Metab, 2018
Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases.A structured search of bibliographic databases - Web of Science Core Collection, Scopus and Medline for peer-reviewed articles on models of DILI was performed.
Kuna L, Bozic I, Kizivat T, Bojanic K, Mrso M, Kralj E, Smolic R, Wu GY, Smolic M.   +8 more
europepmc   +5 more sources

Drug-induced liver injury. Part I: Classification, diagnosis and treatment

Clinical & Experimental Hepatology
Drug-induced liver injury (DILI) is a growing clinical problem. Antibiotics remain the most common cause of DILI in Europe. Their clinical spectrum is very broad, from asymptomatic to acute liver failure. Currently, DILI is categorized as hepatocellular (
Dorota M. Kozielewicz, Piotr Stalke, Julita Skrzypek   +2 more
doaj   +2 more sources

The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment. [PDF]

Metabolites, 2022
Drug-induced liver injury (DILI) is one of the most frequent adverse clinical reactions and a relevant cause of morbidity and mortality. Hepatotoxicity is among the major reasons for drug withdrawal during post-market and late development stages, representing a major concern to the pharmaceutical industry.
Moreno-Torres M, Quintás G, Castell JV.
europepmc   +6 more sources

When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network. [PDF]

Am J Gastroenterol, 2023
INTRODUCTION: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy.
Barritt AS, Barnhart H, Gu J, Dellinger A, Rudnick S, Bonkovsky HL, DILIN Investigators.   +6 more
europepmc   +3 more sources

Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing. [PDF]

Pharmaceutics, 2022
Bile acids and bile salts (BA/BS) are substrates of both influx and efflux transporters on hepatocytes. Canalicular efflux transporters, such as BSEP and MRP2, are crucial for the removal of BA/BS to the bile. Basolateral influx transporters, such as NTCP, OATP1B1/1B3, and OSTα/β, cooperate with canalicular transporters in the transcellular vectorial ...
Tátrai P, Erdő F, Krajcsi P.
europepmc   +4 more sources

A Rare Case of Drug-Induced Liver Injury (DILI) From Topiramate. [PDF]

Cureus
A 72-year-old male individual with a past medical history of seizures and ongoing management with topiramate for two months presented at the emergency department with jaundice. Ten days before the presentation, the patient started feeling fatigued and had intermittent generalized mild pain (grade 3/10) with dark-brown discoloration of urine.
Macasaet R, Payal F, Yagnik K, Rathod M, Aquino D, Shah S.   +5 more
europepmc   +3 more sources

Overview of Causality Assessment for Drug-Induced Liver Injury (DILI) in Clinical Trials. [PDF]

Drug Saf, 2021
Causality assessment for suspected drug-induced liver injury (DILI) during drug development and following approval is challenging. The IQ DILI Causality Working Group (CWG), in collaboration with academic and regulatory subject matter experts (SMEs), developed this manuscript with the following objectives: (1) understand and describe current practices;
Hey-Hadavi J, Seekins D, Palmer M, Coffey D, Caminis J, Abdullaev S, Patwardhan M, Tyler H, Raheja R, Stanley AM, Pineda-Salgado L, Bourdet DL, Andrade RJ, Hayashi PH, Dimick-Santos L, Rockey DC, Estilo A.   +16 more
europepmc   +5 more sources

Comment: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment. [PDF]

Ann Pharmacother, 2021
Danjuma M, Elgara M, Al-Hattab F, Abaro R, Elzouki AN.   +4 more
europepmc   +4 more sources

Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues. [PDF]

Ann Transl Med, 2021
Clinical features of idiosyncratic drug induced liver injury (DILI) are well described in cases that have been assessed for causality using the Roussel Uclaf Causality Assessment Method (RUCAM), but our understanding of the mechanistic steps leading to injury is fragmentary.
Teschke R, Uetrecht J.
europepmc   +4 more sources

Mortality associated with drug-induced liver injury (DILI). [PDF]

Transl Gastroenterol Hepatol, 2017
Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver failure and liver injury leading to transplantation, although in most cases self-remitting when administration of the offending drug is stopped (1-3). In rare cases DILI can lead to a persistent/chronic form of injury (4).
Björnsson ES, Björnsson HK.
europepmc   +4 more sources