Drug-induced liver injury (DILI) - mechanisms and diagnostic [PDF]
Farmacja Polska, 2022 The drug-induced liver injury (DILI) is one of the leading causes of the liver disease in developed countries. These injuries may be the result of constant drug hepatotoxicity or idiosyncrasy associated with the drug or its metabolite.
Marta Małysz +3 more
doaj +2 more sources
When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network. [PDF]
Am J Gastroenterol, 2023 INTRODUCTION: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy.
Barritt AS +6 more
europepmc +3 more sources
The Potential Role of Metabolomics in Drug-Induced Liver Injury (DILI) Assessment. [PDF]
Metabolites, 2022 Drug-induced liver injury (DILI) is one of the most frequent adverse clinical reactions and a relevant cause of morbidity and mortality. Hepatotoxicity is among the major reasons for drug withdrawal during post-market and late development stages, representing a major concern to the pharmaceutical industry.
Moreno-Torres M, Quintás G, Castell JV.
europepmc +6 more sources
Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing. [PDF]
Pharmaceutics, 2022 Bile acids and bile salts (BA/BS) are substrates of both influx and efflux transporters on hepatocytes. Canalicular efflux transporters, such as BSEP and MRP2, are crucial for the removal of BA/BS to the bile. Basolateral influx transporters, such as NTCP, OATP1B1/1B3, and OSTα/β, cooperate with canalicular transporters in the transcellular vectorial ...
Tátrai P, Erdő F, Krajcsi P.
europepmc +4 more sources
A Rare Case of Drug-Induced Liver Injury (DILI) From Topiramate. [PDF]
CureusA 72-year-old male individual with a past medical history of seizures and ongoing management with topiramate for two months presented at the emergency department with jaundice. Ten days before the presentation, the patient started feeling fatigued and had intermittent generalized mild pain (grade 3/10) with dark-brown discoloration of urine.
Macasaet R +5 more
europepmc +3 more sources
Overview of Causality Assessment for Drug-Induced Liver Injury (DILI) in Clinical Trials. [PDF]
Drug Saf, 2021 Causality assessment for suspected drug-induced liver injury (DILI) during drug development and following approval is challenging. The IQ DILI Causality Working Group (CWG), in collaboration with academic and regulatory subject matter experts (SMEs), developed this manuscript with the following objectives: (1) understand and describe current practices;
Hey-Hadavi J +16 more
europepmc +5 more sources
Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues. [PDF]
Ann Transl Med, 2021 Clinical features of idiosyncratic drug induced liver injury (DILI) are well described in cases that have been assessed for causality using the Roussel Uclaf Causality Assessment Method (RUCAM), but our understanding of the mechanistic steps leading to injury is fragmentary.
Teschke R, Uetrecht J.
europepmc +4 more sources
Mortality associated with drug-induced liver injury (DILI). [PDF]
Transl Gastroenterol Hepatol, 2017 Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver failure and liver injury leading to transplantation, although in most cases self-remitting when administration of the offending drug is stopped (1-3). In rare cases DILI can lead to a persistent/chronic form of injury (4).
Björnsson ES, Björnsson HK.
europepmc +4 more sources
Case of cholestatic drug-induced liver injury (DILI) associated with black cohosh. [PDF]
BMJ Case Rep, 2021 Drug-induced liver injury is an uncommon yet fatal cause of liver injury. Black cohosh is a herbal supplement that is derived from Actaea racemosa. It has been used for vasomotor symptoms in postmenopausal women, but it can cause liver injury. A 50-year-old Afro-American woman presented with a 2-month history of malaise, itching and severe jaundice ...
Brar HS, Marathi R.
europepmc +3 more sources
Comment: Drug-Induced Liver Injury (DILI) With Micafungin: The Importance of Causality Assessment. [PDF]
Ann Pharmacother, 2021 Danjuma M +4 more
europepmc +4 more sources