Results 101 to 110 of about 2,763,456 (221)
Pharmacological Research - Modern Chinese Medicine, 2023 Introduction: A growing body of evidence has suggested that Polygonum multiflorum Thunb. (PM) may cause PM-herb-induced liver injury (PM-HILI). However, the compounds triggering PM-HILI remain controversial.
Xiaowen Hu +5 more
doaj
Protein & Cell, 2017 Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive.
Yuewen Tang, Lin Cheng
doaj +1 more source
Scientific ReportsChronic liver injury induces fibrosis that often proceeds to cirrhosis and hepatocellular carcinoma, indicating that prevention and/or resolution of fibrosis is a promising therapeutic target.
Yasuhiro Nakano +5 more
doaj +1 more source
Image segmentation of liver stage malaria infection with spatial uncertainty sampling [PDF]
arXiv, 2019 Global eradication of malaria depends on the development of drugs effective against the silent, yet obligate liver stage of the disease. The gold standard in drug development remains microscopic imaging of liver stage parasites in in vitro cell culture models.
arxiv
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2011 The liver subjected to a number of disorders caused by chemicals namely as hepatotoxicity. carbon tetrachloride (CCl4) the most wildly used in induction of liver injury as a hepatotoxic model for scientific researches.
Said A.M. +3 more
doaj +1 more source
Charakterisierung der Chemikalien-induzierten Leberschädigung („Drug-Induced Liver Injury“ – DILI)
, 2017 The aim of the presented PhD thesis was the development of a new in vitro test system which allows for a better characterization and prediction of drug- induced liver injuries (DILI). After the initial damage of hepatocytes, the activation of the immune system can aggravate this damage and lead to severe liver failure. This important interaction should
openaire +2 more sources
Reaction-Diffusion-Delay Model for EPO/TNF-$α$? Interaction in Articular Cartilage Lesion Abatement [PDF]
arXiv, 2011 Injuries to articular cartilage result in the development of lesions that form on the surface of the cartilage. Such lesions are associated with articular cartilage degeneration and osteoarthritis. The typical injury response often causes collateral damage, primarily an effect of inflammation, which results in the spread of lesions beyond the region ...
arxiv
Predicting Drug-Induced Liver Injury with Bayesian Machine Learning.
Chemical Research in Toxicology, 2019 Drug induced liver injury (DILI) can require significant risk management in drug development, and on occasion can cause morbidity or mortality, leading to drug attrition.
Dominic P. Williams +4 more
semanticscholar +1 more source
Majalah Kedokteran BandungThe liver is the largest organ in the body, composed of both parenchymal and non-parenchymal cells. Chemical substances and various drugs can induce liver injury and involve Kupffer cells which are non-parenchymal cells that release biologically active ...
Agni Febrina Pargaputri +2 more
doaj +1 more source
In Vitro Vascularized Liver and Tumor Tissue Microenvironments on a Chip for Dynamic Determination of Nanoparticle Transport and Toxicity [PDF]
arXiv, 2018 This paper presents the development of a vascularized breast tumor and healthy or tumorigenic liver microenvironments-on-a-chip connected in series. This is the first description of a vascularized multi tissue-on-a-chip microenvironment for modeling cancerous breast and cancerous/healthy liver microenvironments, to allow for the study of dynamic and ...
arxiv