Results 111 to 120 of about 2,763,456 (221)

Hepatotoxicity of antipsychotics: an exploratory pharmacoepidemiologic and pharmacodynamic study integrating FAERS data and in vitro receptor-binding affinities

Frontiers in Psychiatry
IntroductionAntipsychotic psychopharmacotherapy is associated with the risk of drug-induced liver injury (DILI). However, understanding specific risk factors remains challenging due to limited data.
René Zeiss, Carlos Schönfeldt-Lecuona, Bernhard J. Connemann, Susanne Hafner, Maximilian Gahr   +4 more
doaj   +1 more source

CYP3A Mediated Ketamine Metabolism is Severely Impaired in Liver S9 Fractions from Aging Sprague Dawley Rats [PDF]

arXiv, 2015
Ketamine is widely used in veterinary medicine and in medicine. Ketamine is metabolized to its active metabolite norketamine principally by liver CYP3A. Drug metabolism alterations during aging have severe consequences particularly in anesthesiology and very few studies on older animals were conducted for ketamine. The objective of the present study is
arxiv  

Simulation-calibration testing for inference in Lasso regressions [PDF]

arXiv
We propose a test of the significance of a variable appearing on the Lasso path and use it in a procedure for selecting one of the models of the Lasso path, controlling the Family-Wise Error Rate. Our null hypothesis depends on a set A of already selected variables and states that it contains all the active variables.
arxiv  

Understanding Immune Dynamics in Liver Transplant Through Mathematical Modeling [PDF]

arXiv
Liver transplant can be a life-saving procedure for patients with end-stage liver disease. With the introduction of modern immunosuppressive therapies, short-term survival has significantly improved. However, long-term survival has not substantially improved in decades.
arxiv  

Comparison of the Postoperative Liver Function Between Total Intravenous Anesthesia and Inhalation Anesthesia in Patients with Preoperatively Elevated Liver Transaminase Levels: A Retrospective Cohort Study

Therapeutics and Clinical Risk Management, 2020
Seok Kyeong Oh, Byung Gun Lim, Young Sung Kim, Seong Shin Kim Department of Anesthesiology and Pain Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of KoreaCorrespondence: Byung Gun Lim Email bglim9205 ...
Oh SK, Lim BG, Kim YS, Kim SS
doaj  

Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction

, 2020
Wojciech Lesiński, Krzysztof Mnich, Agnieszka Kitlas Golińska, Witold R. Rudnicki   +3 more
openalex   +1 more source

Surgical Workflow Recognition and Blocking Effectiveness Detection in Laparoscopic Liver Resections with Pringle Maneuver [PDF]

AAAI 2025
Pringle maneuver (PM) in laparoscopic liver resection aims to reduce blood loss and provide a clear surgical view by intermittently blocking blood inflow of the liver, whereas prolonged PM may cause ischemic injury. To comprehensively monitor this surgical procedure and provide timely warnings of ineffective and prolonged blocking, we suggest two ...
arxiv  

Drug-induced liver injury in children: A nationwide cohort study from China

JHEP Reports
Background & Aims: Currently, there is limited knowledge on the clinical profile of drug-induced liver injury (DILI) in Chinese children. We aimed to assess the clinical characteristics, suspected drugs, and outcomes associated with pediatric DILI in
Rongtao Lai, Xinjie Li, Jie Zhang, Jun Chen, Changqing Yang, Wen Xie, Yuecheng Yu, Xiaoyan Guo, Xinrong Zhang, Guoliang Lu, Xi’an Han, Qing Xie, Chengwei Chen, Tao Shen, Yimin Mao   +14 more
doaj  

Clinical factors predicting drug-induced liver injury due to flucloxacillin

Drug, Healthcare and Patient Safety, 2018
Mikaela Lindh,1 Pär Hallberg,1 Qun-Ying Yue,2 Mia Wadelius1 1Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; 2Swedish Medical Products Agency, Uppsala, Sweden Objectives ...
Lindh M, Hallberg P, Yue QY, Wadelius M
doaj  

Nimbolide Targeting SIRT1 Protects Against Acetaminophen-Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress. [PDF]

Pharmacol Res Perspect
Ba J, Lin Y, Zhang J, Wang Y, Wu B.
europepmc   +1 more source