Results 121 to 130 of about 92,867 (160)

Cannabidiol-Ion Channel Interactions Represent a Promising Preventive and Therapeutic Strategy in Hepatocellular Carcinoma. [PDF]

Pathophysiology
Chávez-López MG, Avalos-Fuentes A, Cruz-Manzo EDC, Aguirre-Arriaga PA, Florán B, Pérez-Carreón JI, Bañuelos C, Camacho J.   +7 more
europepmc   +1 more source

AMPK maintains the activation of hepatic stellate cells through mitophagy-induced metabolic reprogramming. [PDF]

J Mol Cell Biol
Wang H, Wang G, Yin T, Li H, Wang H, Shao Y, Li Y, Hua R, Li J, Zang Y.   +9 more
europepmc   +1 more source

Dynamic chemical labelling accurately quantifies microRNA-122 and reveals the presence of isomiRs that compromise PCR-based analysis in drug-induced liver injury

, 2019
Dear, James, López-Longarela, Barbara, Morrison, Emma, Tranter, John David, Ilyine, Hugh, Duffy, David, Diaz-Mochon, Juan   +6 more
openaire   +1 more source

Ferroptosis: action and mechanism of chemical/drug-induced liver injury

Drug and Chemical Toxicology, 2023
Drug-induced liver injury (DILI) is characterized by hepatocyte injury, cholestasis injury, and mixed injury. The liver transplantation is required for serious clinical outcomes such as acute liver failure. Current studies have found that many mechanisms were involved in DILI, such as mitochondrial oxidative stress, apoptosis, necroptosis, autophagy ...
Li Zeng, Xueli Jin, Qing-Ao Xiao, Wei Jiang, Shanshan Han, Jin Chao, Ding Zhang, Xuan Xia, Decheng Wang   +8 more
openaire   +3 more sources

Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries

Toxicology and Applied Pharmacology, 2012
Although estrogen receptor (ER)α agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury caused by hepatotoxicants as well as ischemia-reperfusion. The functional mechanisms of ERα have yet to be elucidated in drug-induced or chemical-induced liver injury.
Yukitaka, Yoshikawa, Taishi, Miyashita, Satonori, Higuchi, Koichi, Tsuneyama, Shinya, Endo, Tohru, Tsukui, Yasuyuki, Toyoda, Tatsuki, Fukami, Miki, Nakajima, Tsuyoshi, Yokoi   +9 more
openaire   +3 more sources

Simplified Test for Determination of Drug‐Oxidizing Capacity in Rats with Chemical‐Induced Liver Injury Using Caffeine and Trimethadione as Model Drugs

Pharmacology & Toxicology, 1992
Abstract:We examined the possibility of predicting the extent of hepatic drug‐oxidizing capacity by determination of caffeine, trimethadione and their metabolites in three groups of rats with chemically induced liver injuries. Trimethadione (4 mg/kg) and caffeine (10 mg/kg) were simultaneously administered as two probe drugs.
E, Tanaka, A, Ishikawa, S, Misawa
openaire   +3 more sources

Hybrid in silico models for drug‐induced liver injury using chemical descriptors and in vitro cell‐imaging information

Journal of Applied Toxicology, 2013
ABSTRACTDrug‐induced liver injury (DILI) is a major adverse drug reaction that accounts for one‐third of post‐marketing drug withdrawals. Several classifiers for human hepatotoxicity using chemical descriptors with limited prediction accuracies have been published.
Xiang-Wei, Zhu, Alexander, Sedykh, Shu-Shen, Liu   +2 more
openaire   +3 more sources