Results 121 to 130 of about 2,829,330 (224)
Pharmacological Research - Modern Chinese Medicine, 2023 Introduction: A growing body of evidence has suggested that Polygonum multiflorum Thunb. (PM) may cause PM-herb-induced liver injury (PM-HILI). However, the compounds triggering PM-HILI remain controversial.
Xiaowen Hu +5 more
doaj
Protein & Cell, 2017 Tissue damage induces cells into reprogramming-like cellular state, which contributes to tissue regeneration. However, whether factors promoting the cell reprogramming favor tissue regeneration remains elusive.
Yuewen Tang, Lin Cheng
doaj +1 more source
Scientific ReportsChronic liver injury induces fibrosis that often proceeds to cirrhosis and hepatocellular carcinoma, indicating that prevention and/or resolution of fibrosis is a promising therapeutic target.
Yasuhiro Nakano +5 more
doaj +1 more source
Image segmentation of liver stage malaria infection with spatial uncertainty sampling [PDF]
arXiv, 2019 Global eradication of malaria depends on the development of drugs effective against the silent, yet obligate liver stage of the disease. The gold standard in drug development remains microscopic imaging of liver stage parasites in in vitro cell culture models.
arxiv
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2011 The liver subjected to a number of disorders caused by chemicals namely as hepatotoxicity. carbon tetrachloride (CCl4) the most wildly used in induction of liver injury as a hepatotoxic model for scientific researches.
Said A.M. +3 more
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Charakterisierung der Chemikalien-induzierten Leberschädigung („Drug-Induced Liver Injury“ – DILI)
, 2017 The aim of the presented PhD thesis was the development of a new in vitro test system which allows for a better characterization and prediction of drug- induced liver injuries (DILI). After the initial damage of hepatocytes, the activation of the immune system can aggravate this damage and lead to severe liver failure. This important interaction should
openaire +2 more sources
Reaction-Diffusion-Delay Model for EPO/TNF-$α$? Interaction in Articular Cartilage Lesion Abatement [PDF]
arXiv, 2011 Injuries to articular cartilage result in the development of lesions that form on the surface of the cartilage. Such lesions are associated with articular cartilage degeneration and osteoarthritis. The typical injury response often causes collateral damage, primarily an effect of inflammation, which results in the spread of lesions beyond the region ...
arxiv
In Vitro Vascularized Liver and Tumor Tissue Microenvironments on a Chip for Dynamic Determination of Nanoparticle Transport and Toxicity [PDF]
arXiv, 2018 This paper presents the development of a vascularized breast tumor and healthy or tumorigenic liver microenvironments-on-a-chip connected in series. This is the first description of a vascularized multi tissue-on-a-chip microenvironment for modeling cancerous breast and cancerous/healthy liver microenvironments, to allow for the study of dynamic and ...
arxiv
Frontiers in PsychiatryIntroductionAntipsychotic psychopharmacotherapy is associated with the risk of drug-induced liver injury (DILI). However, understanding specific risk factors remains challenging due to limited data.
René Zeiss +4 more
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CYP3A Mediated Ketamine Metabolism is Severely Impaired in Liver S9 Fractions from Aging Sprague Dawley Rats [PDF]
arXiv, 2015 Ketamine is widely used in veterinary medicine and in medicine. Ketamine is metabolized to its active metabolite norketamine principally by liver CYP3A. Drug metabolism alterations during aging have severe consequences particularly in anesthesiology and very few studies on older animals were conducted for ketamine. The objective of the present study is
arxiv