Results 271 to 280 of about 198,086 (334)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Advanced Strategies in Enhancing the Hepatoprotective Efficacy of Natural Products: Integrating Nanotechnology, Genomics, and Mechanistic Insights. [PDF]

ACS Biomater Sci Eng
Patel J, Roy H, Chintamaneni PK, Patel R, Bohara R.   +4 more
europepmc   +1 more source

Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism. [PDF]

Front Pharmacol
Hu M, Hua X, Xiong W, Zheng E, Yang X, Lu Y, He B, Zhong X, Jiang Z, Zhang Q, Liu Y.   +10 more
europepmc   +1 more source

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation. [PDF]

iScience
Kunnen SJ, Callegaro G, Sutherland JJ, Trairatphisan P, van Kessel HW, Wijaya LS, Chung G, Pye K, Goldstein KM, Teague CR, Fisher CP, Saez-Rodriguez J, Brown C, Elmore SA, Heinz-Taheny KM, Stevens JL, van de Water B.   +16 more
europepmc   +1 more source

MRI findings of confluent hepatic fibrosis caused by different etiologies. [PDF]

BMC Gastroenterol
Yu D, Li XH, He XL, Jia XB, Wang ZC, Yang ZH, Ren AH.   +6 more
europepmc   +1 more source

Dynamic chemical labelling accurately quantifies microRNA-122 and reveals the presence of isomiRs that compromise PCR-based analysis in drug-induced liver injury

, 2019
Dear, James, López-Longarela, Barbara, Morrison, Emma, Tranter, John David, Ilyine, Hugh, Duffy, David, Diaz-Mochon, Juan   +6 more
openaire   +1 more source

Ferroptosis: action and mechanism of chemical/drug-induced liver injury

Drug and Chemical Toxicology, 2023
Drug-induced liver injury (DILI) is characterized by hepatocyte injury, cholestasis injury, and mixed injury. The liver transplantation is required for serious clinical outcomes such as acute liver failure. Current studies have found that many mechanisms
Li Zeng, Xueli Jin, Qing-Ao Xiao, Wei Q. Jiang, Shanshan Han, Jin Chao, Ding Zhang, Xuan Xia, Decheng Wang   +8 more
semanticscholar   +4 more sources

Chemical Probes for drug-induced Liver Injury Imaging

Future Medicinal Chemistry, 2020
Drug-induced liver injury (DILI) has been a long-standing concern of modern medicine, and the single most frequent reason for drug nonapprovals and postapproval restrictions or withdrawals.
Jiang Tao, Pengfei Rong, Wei Wang
semanticscholar   +5 more sources