Results 271 to 280 of about 194,011 (303)

Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury

Chemical Research in Toxicology, 2019
Idiosyncratic drug-induced liver injury (iDILI), which is rare and often recognized only late in drug development, poses a major public health concern and impediment to drug development due to its high rate of morbidity and mortality. The mechanisms of DILI are not completely understood; both non-immune- and immune-mediated mechanisms have been ...
Serat-E Ali, J. Waddington, B. Kevin Park, Xiaoli Meng   +3 more
openalex   +3 more sources

A comprehensive review of Dynamic Chemical Labelling on Luminex xMAP technology: a journey towards Drug-Induced Liver Injury testing

Analytical Methods, 2023
By integrating Dynamic Chemical Labelling (DCL) with Luminex xMAP technology, it becomes feasible to analyse miRs through single- and multi-plex assays, as well as to simultaneously analyse proteins and miRs.
Antonio Marín-Romero, Salvatore Pernagallo   +1 more
openalex   +3 more sources

The chemical, genetic and immunological basis of idiosyncratic drug–induced liver injury [PDF]

Human & Experimental Toxicology, 2015
Idiosyncratic drug reactions can be extremely severe and are not accounted for by the regular pharmacology of a drug. Thus, the mechanism of idiosyncratic drug–induced liver injury (iDILI), a phenomenon that occurs with many drugs including β-lactams, anti-tuberculosis drugs and non-steroidal anti-inflammatories, has been difficult to determine and ...
Arun Tailor, L Faulkner, Dean J. Naisbitt, BK Park   +3 more
openalex   +3 more sources

Mechanisms of the hepatoprotective effects of tamoxifen against drug-induced and chemical-induced acute liver injuries

Toxicology and Applied Pharmacology, 2012
Although estrogen receptor (ER)α agonists, such as estradiol and ethinylestradiol (EE2), cause cholestasis in mice, they also reduce the degree of liver injury caused by hepatotoxicants as well as ischemia-reperfusion. The functional mechanisms of ERα have yet to be elucidated in drug-induced or chemical-induced liver injury.
Yukitaka Yoshikawa, Taishi Miyashita, Satonori Higuchi, Koichi Tsuneyama, Shinya Endo, Tohru Tsukui, Yasuyuki Toyoda, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi   +9 more
openalex   +3 more sources

Simplified Test for Determination of Drug‐Oxidizing Capacity in Rats with Chemical‐Induced Liver Injury Using Caffeine and Trimethadione as Model Drugs

Pharmacology & Toxicology, 1992
Abstract:We examined the possibility of predicting the extent of hepatic drug‐oxidizing capacity by determination of caffeine, trimethadione and their metabolites in three groups of rats with chemically induced liver injuries. Trimethadione (4 mg/kg) and caffeine (10 mg/kg) were simultaneously administered as two probe drugs.
Einosuke Tanaka, Akio Ishikawa, Shogo Misawa   +2 more
openalex   +3 more sources

Morin: a promising hepatoprotective agent against drug and chemical-induced liver injury

Naunyn-Schmiedeberg's Archives of Pharmacology
Pandi Anandakumar, N. B. Sen, Vanitha Manickam Kalappan, Vanita Lal   +3 more
openalex   +2 more sources

Hybrid in silico models for drug‐induced liver injury using chemical descriptors and in vitro cell‐imaging information

Journal of Applied Toxicology, 2013
ABSTRACTDrug‐induced liver injury (DILI) is a major adverse drug reaction that accounts for one‐third of post‐marketing drug withdrawals. Several classifiers for human hepatotoxicity using chemical descriptors with limited prediction accuracies have been published.
Xiang‐Wei Zhu, Alexander Sedykh, Shu‐Shen Liu   +2 more
openalex   +3 more sources

Biochemical and morphological study of the liver injury induced by drugs and chemicals.

Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1979
Lai My, Sung Jl, Lin Ws, How Sw, Yü Jy, Wang Th, Ding‐Shinn Chen   +6 more
openalex   +2 more sources

[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976
Erik Dybing
openalex   +2 more sources

Evaluation of 3-D bioprinted human liver tissue for assessment drug-induced liver injury across a diverse set of chemical classes

Toxicology Letters, 2017
Jeffrey Irelan, Candace Crogan‐Grundy, Ryan P. Smith, Rhiannon N. Hardwick, Deborah G. Nguyen   +4 more
openalex   +2 more sources