Results 271 to 280 of about 197,386 (292)
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A comprehensive review of Dynamic Chemical Labelling on Luminex xMAP technology: a journey towards Drug-Induced Liver Injury testing

Analytical Methods, 2023
By integrating Dynamic Chemical Labelling (DCL) with Luminex xMAP technology, it becomes feasible to analyse miRs through single- and multi-plex assays, as well as to simultaneously analyse proteins and miRs.
Antonio Marín-Romero   +1 more
openaire   +2 more sources

Simplified Test for Determination of Drug‐Oxidizing Capacity in Rats with Chemical‐Induced Liver Injury Using Caffeine and Trimethadione as Model Drugs

Pharmacology & Toxicology, 1992
Abstract:We examined the possibility of predicting the extent of hepatic drug‐oxidizing capacity by determination of caffeine, trimethadione and their metabolites in three groups of rats with chemically induced liver injuries. Trimethadione (4 mg/kg) and caffeine (10 mg/kg) were simultaneously administered as two probe drugs.
E, Tanaka, A, Ishikawa, S, Misawa
openaire   +2 more sources

Morin: a promising hepatoprotective agent against drug and chemical-induced liver injury

Naunyn-Schmiedeberg's Archives of Pharmacology
Morin, a naturally occurring flavonoid found in various fruits and medicinal plants, has long been recognized in ethnopharmacological practices for its therapeutic potential. While its antioxidant and anti-inflammatory properties have been appreciated historically, recent molecular studies have begun to uncover the precise mechanisms underlying its ...
Anandakumar, Pandi   +3 more
openaire   +2 more sources

Hybrid in silico models for drug‐induced liver injury using chemical descriptors and in vitro cell‐imaging information

Journal of Applied Toxicology, 2013
ABSTRACTDrug‐induced liver injury (DILI) is a major adverse drug reaction that accounts for one‐third of post‐marketing drug withdrawals. Several classifiers for human hepatotoxicity using chemical descriptors with limited prediction accuracies have been published.
Xiang-Wei, Zhu   +2 more
openaire   +2 more sources

Drug-induced liver injury

Nature Reviews Disease Primers, 2019
Raúl J Andrade   +2 more
exaly   +2 more sources

Biochemical and morphological study of the liver injury induced by drugs and chemicals.

Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association, 1979
M Y, Lai   +6 more
openaire   +1 more source

Drug-Induced Liver Injury — Types and Phenotypes

New England Journal of Medicine, 2019
Einar S Björnsson
exaly  

Evaluation of 3-D bioprinted human liver tissue for assessment drug-induced liver injury across a diverse set of chemical classes

Toxicology Letters, 2017
Jeffrey Irelan   +4 more
openaire   +1 more source

Corticosteroid therapy in drug‐induced liver injury: Pros and cons

Journal of Digestive Diseases, 2019
Wei-Fen Xie
exaly  

In silicomodels for drug-induced liver injury – current status

Expert Opinion on Drug Metabolism and Toxicology, 2012
Mark T D Cronin
exaly  

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