Results 21 to 30 of about 461,600 (257)

Yin-yang in drug discovery: rethinking de novo design and development of predictive models

Frontiers in Drug Discovery, 2023
Chemical and biological data are the cornerstone of modern drug discovery programs. Finding qualitative yet better quantitative relationships between chemical structures and biological activity has been long pursued in medicinal chemistry and drug ...
Ana L. Chávez-Hernández, Edgar López-López, Edgar López-López, José L. Medina-Franco   +3 more
doaj   +1 more source

Bacterial degradation of a plant toxin and nutrient competition with commensals trade off to constrain pathogen growth

mSystems
Healthy plant leaves potentially host both commensal bacteria and opportunistic pathogens, which, under some circumstances, may cause disease. The interactions between commensals and opportunistic pathogens are generally poorly understood, but such ...
Marco Mauri, Kerstin Unger, Jonathan Gershenzon, Rosalind J. Allen, Matthew T. Agler   +4 more
doaj   +1 more source

Measurable Residual Disease Monitoring During Treatment for Pediatric Acute Myeloid Leukemia in First Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survival after relapse in pediatric acute myeloid leukemia (AML) remains poor, highlighting the critical importance of identifying prognostic factors to guide optimal relapse management. Methods We investigated the prognostic impact of multiparameter flow cytometry (MFC) measurable residual disease (MRD) in 188 patients with first ...
Camilla Poulsen, Kristian Juul Sandahl, Lene Karlsson, Jonas Abrahamsson, Nira Arad‐Cohen, Daniel Cheuk, Barbara De Moerloose, Linda Fogelstrand, Jose Maria Fernandez Navarro, Bianca F. Goemans, Kirsi Jahnukainen, Gertjan Kaspers, Zhanna Kovalova, Monica Cheng Munthe‐Kaas, Ulrika Norén‐Nyström, Josefine Palle, Ramune Pasauliene, Cornelis Jan Pronk, Kadri Saks, Anne Tierens, Henrik Hasle, Kristian Løvvik Juul‐Dam   +21 more
wiley   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance

Contemporary Clinical Trials Communications, 2020
The literature is replete with clinical studies that characterize the structure, diversity, and function of the gut microbiome and correlate the results to different disease states, including obesity. Whether the microbiome has a direct impact on obesity
Karen D. Corbin, Rosa Krajmalnik-Brown, Elvis A. Carnero, Christopher Bock, Rita Emerson, Bruce E. Rittmann, Andrew K. Marcus, Taylor Davis, Blake Dirks, Zehra Esra Ilhan, Catherine Champagne, Steven R. Smith   +11 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The mass transfer of chemical elements and of their compounds in agrocenoses

Бюллетень Почвенного института им. В.В. Докучаева, 2022
The analysis of publications on the mass transfer of chemical elements in agrocenosis in the soil – plant system was carried out. Methods for estimating the content of mobile forms of chemical compounds coming from the soil into plants are considered ...
T. I. Borisochkina, A. D. Kotelnikova, O. B. Rogova   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A quasi chemical approach for the modeling of predator-prey interactions [PDF]

Network Biology, 2014
We aim to develop the reaction diffusion equation for different types of mechanism of the predator-prey interactions with quasi chemical approach. The chemical reactions representing the interactions obey the mass action law.
Muhammad Shakil, H. A. Wahab, Muhammad Naeem, et al.   +2 more
doaj  

Chemical cannibalistic cues make damselfly larvae hide rather than hunt

Scientific Reports, 2023
Adopting cannibalism substantially affects individual fitness, and recognizing the presence of other cannibals provides additional benefits such as the opportunity to prepare for hunting or defense.
Monika Sysiak, Barbara Pietrzak, Matylda Kubiak, Anna Bednarska, Andrzej Mikulski   +4 more
doaj   +1 more source