Results 31 to 40 of about 461,600 (257)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Global DNA-methylation in quantitative epigenetics: orbitrap mass spectrometry

Frontiers in Molecular Biosciences
DNA methylation is the most common epigenetic modification in both prokaryotic and eukaryotic genomes. Here we present a method based on highly efficient acid-hydrolysis of DNA, liquid chromatography, and detection by mass spectrometry to accurately ...
Janine F. M. Otto, Georg Pohnert, Georg Pohnert, Thomas Wichard, Michael Bauer, Michael Bauer, Anne Busch, Anne Busch, Anne Busch, Nico Ueberschaar   +9 more
doaj   +1 more source

Adaptation ukrainian legislation on regulation of manufacture and use of chemicals with EU norms on the basis of partnership and cooperation agreement 1994.

Теорія і практика правознавства, 2016
The EU countries have realised necessity of a legal regulation of the chemical substances for health protection of the person and maintenance of natural balance.
О. С. Бабенко
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Synergy between Data Reconciliation and Principal Component Analysis in Energy Monitoring

Chemical Engineering Transactions, 2014
Monitoring of energy consumption is central importance for the energy-efficient operation of chemical processes. Fault detection and process monitoring systems can reduce the environmental impact and enhance safety and energy efficiency of chemical ...
B. Farsang, S. Németh, J. Abonyi
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Calcário, Potássio, Fosfato e Silício na produtividade do solo = Lime, Potassium, Phosphate and Silicon in the productivity of the soil

Acta Scientiarum. Agronomy, 2006
Visando melhorar a disponibilidade do fósforo no solo foi realizado um estudo de sorção de fósforo, utilizando CALPOT (calcário + potássio) e silício como promotores. Em laboratório, aplicou-se ao solo os elementos P e Si em doses crescentes e CALPOT com
Geraldo Estevam de Souza Carneiro, Inês Cristina Batista Fonseca, Roberto Antunes Fioretto, Cristine Elizabeth Alvarenga Carneiro   +3 more
doaj  

Approaching coupled cluster accuracy with a general-purpose neural network potential through transfer learning

Nature Communications, 2019
Computational modelling of chemical systems requires a balance between accuracy and computational cost. Here the authors use transfer learning to develop a general purpose neural network potential that approaches quantum-chemical accuracy for reaction ...
Justin S. Smith, Benjamin T. Nebgen, Roman Zubatyuk, Nicholas Lubbers, Christian Devereux, Kipton Barros, Sergei Tretiak, Olexandr Isayev, Adrian E. Roitberg   +8 more
doaj   +1 more source

Evaluation of optimization methods for solving the receptor model for chemical mass balance [PDF]

Journal of the Serbian Chemical Society, 2015
Balance (CMB) model has been extensively used in order to determine source contribution for particulate matters (size diameters less than 10 μm and 2.5 μm) in the air quality analysis.
Anu N., Rangabhashiyam S., Rahul Antony, Selvaraju N.   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source