Results 31 to 40 of about 496,469 (302)
Yin-yang in drug discovery: rethinking de novo design and development of predictive models
Frontiers in Drug Discovery, 2023 Chemical and biological data are the cornerstone of modern drug discovery programs. Finding qualitative yet better quantitative relationships between chemical structures and biological activity has been long pursued in medicinal chemistry and drug ...
Ana L. Chávez-Hernández +3 more
doaj +1 more source
How accurate are the nonlinear chemical Fokker-Planck and chemical Langevin equations? [PDF]
, 2011 The chemical Fokker-Planck equation and the corresponding chemical Langevin equation are commonly used approximations of the chemical master equation.
Straube, AV +5 more
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
, 2017 This paper presents a multi-compartment population balance model for wet granulation coupled with DEM (discrete element method) simulations. Methodologies are developed to extract relevant data from the DEM simulations to inform the population balance ...
McGuire, Andrew D. +6 more
core +1 more source
Contemporary Clinical Trials Communications, 2020 The literature is replete with clinical studies that characterize the structure, diversity, and function of the gut microbiome and correlate the results to different disease states, including obesity. Whether the microbiome has a direct impact on obesity
Karen D. Corbin +11 more
doaj +1 more source
The mass transfer of chemical elements and of their compounds in agrocenoses
Бюллетень Почвенного института им. В.В. Докучаева, 2022 The analysis of publications on the mass transfer of chemical elements in agrocenosis in the soil – plant system was carried out. Methods for estimating the content of mobile forms of chemical compounds coming from the soil into plants are considered ...
T. I. Borisochkina +2 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A quasi chemical approach for the modeling of predator-prey interactions [PDF]
Network Biology, 2014 We aim to develop the reaction diffusion equation for different types of mechanism of the predator-prey interactions with quasi chemical approach. The chemical reactions representing the interactions obey the mass action law.
Muhammad Shakil +2 more
doaj
Synergy between Data Reconciliation and Principal Component Analysis in Energy Monitoring
Chemical Engineering Transactions, 2014 Monitoring of energy consumption is central importance for the energy-efficient operation of chemical processes. Fault detection and process monitoring systems can reduce the environmental impact and enhance safety and energy efficiency of chemical ...
B. Farsang, S. Németh, J. Abonyi
doaj +1 more source
Chemical cannibalistic cues make damselfly larvae hide rather than hunt
Scientific Reports, 2023 Adopting cannibalism substantially affects individual fitness, and recognizing the presence of other cannibals provides additional benefits such as the opportunity to prepare for hunting or defense.
Monika Sysiak +4 more
doaj +1 more source