Results 221 to 230 of about 2,786,318 (328)

Isomalabaricane Chemical Composition of Vietnamese Marine Sponges Inspected by Metabolomic and Chemical Approaches. [PDF]

Mar Drugs
Kolesnikova SA, Kozhushnaya AB, Shilov VA, Kukhlevsky AD, Kalinovsky AI, Popov RS, Dmitrenok PS, Ivanchina NV.   +7 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Climate-Driven Variability in the Chemical Composition and Antioxidant Activity of <i>Allium ursinum</i> L. [PDF]

Antioxidants (Basel)
Radušienė J, Karpavičienė B, Zymone K, Marksa M, Raudone L.   +4 more
europepmc   +1 more source

Physical and Chemical properties, Composition, and Biological Activity of Essential Oils of Philippine Medicinal Plants

, 2016
H. Rodolfo Juliani
openalex   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Chemical composition and ecological adaptation of <i>Populus</i> (Salicaceae) species and hybrids depending on soil and environmental conditions. [PDF]

RSC Adv
Mechshanova A, Berillo D, Polyakov V.
europepmc   +1 more source

Understanding ammonia emissions: the impact of feed chemical composition on dairy Holstein farms

Mirna Gavran, Danko Šinka, Marko Samardžija, Ranko Gantner, Zvonimir Steiner, Vesna Gantner   +5 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Impact of In vitro Gastrointestinal Digestion on the Chemical Composition and Prebiotic Potential of Coffee Silverskin. [PDF]

Plant Foods Hum Nutr
Machado M, Fernandes I, Fernandes A, Espírito Santo L, Passos C, Santamarina A, Cardelle-Cobas A, Coimbra MA, Oliveira MBPP, Ferreira H, Alves RC.   +10 more
europepmc   +1 more source

Nanoparticle Chemical Composition [PDF]

, 2020
openaire   +1 more source