Results 11 to 20 of about 621,408 (312)

In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes [PDF]

Current Protocols in Chemical Biology, 2012
AbstractThe Rapid Assessment of Compound Exposure (RACE) assay is an easy and efficient method for estimating the pharmacokinetic parameter of exposure (AUC: area under the curve) of novel chemical probe compounds in mice. RACE is a truncated and compressed version of a traditional comprehensive in vivo pharmacokinetics study.
Danielle, McAnally, Michael, Vicchiarelli, Khandaker, Siddiquee, Layton H, Smith   +3 more
openaire   +2 more sources

Non-targeted screening methodology to characterise human internal chemical exposure: Application to halogenated compounds in human milk

Talanta, 2021
Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to ...
Mariane Pourchet, Luca Narduzzi, Annabelle Jean, Ingrid Guiffard, Emmanuelle Bichon, Ronan Cariou, Yann Guitton, Sébastien Hutinet, Jelle Vlaanderen, Jeroen Meijer, Bruno Le Bizec, Jean-Philippe Antignac   +11 more
openaire   +5 more sources

Standardised bioassays reveal that mosquitoes learn to avoid compounds used in chemical vector control after a single sub-lethal exposure [PDF]

Scientific Reports, 2022
AbstractVector-borne diseases are worldwide public health issues. Despite research focused on vectorial capacity determinants in pathogen transmitting mosquitoes, their behavioural plasticity remains poorly understood. Memory and associative learning have been linked to behavioural changes in several insect species, but their relevance in behavioural ...
Seynabou Sougoufara, Hanna Yorkston-Dives, Nurul Masyirah Aklee, Adanan Che Rus, Jaal Zairi, Frederic Tripet   +5 more
openaire   +3 more sources

Identification of gp96 as a novel target for treatment of autoimmune disease in mice. [PDF]

PLoS ONE, 2010
Heat shock proteins have been implicated as endogenous activators for dendritic cells (DCs). Chronic expression of heat shock protein gp96 on cell surfaces induces significant DC activations and systemic lupus erythematosus (SLE)-like phenotypes in mice.
Jung Min Han, Nam Hoon Kwon, Jin Young Lee, Seung Jae Jeong, Hee Jung Jung, Hyeong Rae Kim, Zihai Li, Sunghoon Kim   +7 more
doaj   +1 more source

Titanium dioxide nanotubes for production and delivery of nitric oxide and methods for production thereof [PDF]

, 2016
The present disclosure describes compositions operable for releasing nitric oxide under photochemical conditions. The compositions include a titanium dioxide nanomaterial and a nitric oxide-releasing compound deposited on the titanium dioxide ...
Balkus, Kenneth J., Jr., Ratanatawanate, Chalita   +1 more
core   +1 more source

Diathermy smoke: hazardous to health? [PDF]

, 2013
The heat used in electrocautery causes cells to boil and explode, or simply dry up, producing a gaseous by-product known as diathermy smoke. This smoke may have mutagenic and carcinogenic potential, similar to that of cigarette smoke (Spearman et al ...
Brown, Steven, Dunn, Lynda
core   +1 more source

Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme [PDF]

, 2010
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP ...
Andrew C. Hemmert, C. Linn Cadieux, Carol C. Edwards, Douglas M. Cerasoli, Fernando Rodrigues-Lima, John R. Cashman, Jonathan S. Edwards, Lyudmila Tsurkan, Matthew R. Redinbo, Monika Wierdl, Philip M. Potter, Roberto A. Chica, Shane A. Kasten, Stephen L. Mayo, Steven M. Lewis, Tamara C. Otto   +15 more
core   +10 more sources

Suspect screening of maternal serum to identify new environmental chemical biomonitoring targets using liquid chromatography-quadrupole time-of-flight mass spectrometry. [PDF]

, 2017
The use and advantages of high-resolution mass spectrometry (MS) as a discovery tool for environmental chemical monitoring has been demonstrated for environmental samples but not for biological samples.
Friesen, Matthew M, Gerona, Roy R, Lin, Thomas, Pan, Janet, Schwartz, Jackie M, Woodruff, Tracey J   +5 more
core   +1 more source

Bisphenol A – Application, sources of exposure and potential risks in infants, children and pregnant women

International Journal of Occupational Medicine and Environmental Health, 2015
Bisphenol A (BPA) is used in the chemical industry as a monomer in the production of plastics. It belongs to a group of compounds that disturb some of the functions of human body, the endocrine system in particular.
Karolina Mikołajewska, Joanna Stragierowicz, Jolanta Gromadzińska   +2 more
doaj   +1 more source

Translation inhibition by rocaglates activates a species-specific cell death program in the emerging fungal pathogen Candida auris [PDF]

, 2020
Fungal infections are a major contributor to infectious disease-related deaths worldwide. Recently, global emergence of the fungal pathogen Candida auris has caused considerable concern because most C.
Brown, Lauren E., Cowen, Leah E., Henkel, Thomas, Iyer, Kali R., Porco, Jr., John A., Robbins, Nicole, Whitesell, Luke   +6 more
core   +1 more source