Results 11 to 20 of about 257,797 (170)
In Vivo Rapid Assessment of Compound Exposure (RACE) for Profiling the Pharmacokinetics of Novel Chemical Probes [PDF]
Current Protocols in Chemical Biology, 2012 AbstractThe Rapid Assessment of Compound Exposure (RACE) assay is an easy and efficient method for estimating the pharmacokinetic parameter of exposure (AUC: area under the curve) of novel chemical probe compounds in mice. RACE is a truncated and compressed version of a traditional comprehensive in vivo pharmacokinetics study.
Danielle, McAnally +3 more
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Talanta, 2021 Suspect and non-targeted screening approaches are a matter of increasing interest notably with regard to the Exposome contextual framework, but their application to human samples still remains limited at this date. The aim of the present study was to develop a non-targeted workflow from sample preparation to data processing and method assessment to ...
Mariane Pourchet +11 more
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Standardised bioassays reveal that mosquitoes learn to avoid compounds used in chemical vector control after a single sub-lethal exposure [PDF]
Scientific Reports, 2022 AbstractVector-borne diseases are worldwide public health issues. Despite research focused on vectorial capacity determinants in pathogen transmitting mosquitoes, their behavioural plasticity remains poorly understood. Memory and associative learning have been linked to behavioural changes in several insect species, but their relevance in behavioural ...
Seynabou Sougoufara +5 more
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Identification of gp96 as a novel target for treatment of autoimmune disease in mice. [PDF]
PLoS ONE, 2010 Heat shock proteins have been implicated as endogenous activators for dendritic cells (DCs). Chronic expression of heat shock protein gp96 on cell surfaces induces significant DC activations and systemic lupus erythematosus (SLE)-like phenotypes in mice.
Jung Min Han +7 more
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International Journal of Occupational Medicine and Environmental Health, 2015 Bisphenol A (BPA) is used in the chemical industry as a monomer in the production of plastics. It belongs to a group of compounds that disturb some of the functions of human body, the endocrine system in particular.
Karolina Mikołajewska +2 more
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Insects, 2019 Use of neonicotinoid pesticides is now ubiquitous, and consequently non-targeted arthropods are exposed to their residues at sub-lethal doses. Exposure to these neurotoxins may be a major contributor to poor honey bee colony health.
Steven C. Cook
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Food contamination with acrylamide in terms of consumer health risk
Medycyna Ogólna i Nauki o Zdrowiu, 2022 Introduction and objective Food is a basis for proper functioning of the human body. Inadequate quality of consumed food products may have a negative impact on mhuman health.
Agata Piekut +3 more
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STAR Protocols, 2023 Summary: Research rigor can be enhanced by pairing genetic tools with pharmacology and manipulations of solutes or ions. Here, we present a protocol for treating C. elegans with pharmacological agents, osmoles, and salts. We describe steps for agar plate
Lei Wang, Bianca Graziano, Laura Bianchi
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Frontiers in Toxicology, 2023 Assessing chemical safety is essential to evaluate the potential risks of chemical exposure to human health and the environment. Traditional methods relying on animal testing are being replaced by 3R (reduction, refinement, and replacement) principle ...
Giusy del Giudice +47 more
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International Journal of Occupational Medicine and Environmental Health, 2019 Professional drivers are exposed to a number of factors that have a negative influence on their health status. These include vibrations, noise, the lack of fresh air in the car cabin, shift work (frequently at night), monotony resulting from permanent repetition of certain actions, static loads due to immobilization in a sitting position, stress ...
Kozłowska, Lucyna +2 more
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