Results 71 to 80 of about 270,239 (265)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Endocrine disrupting chemicals: harmful substances and how to test them

Cadernos de Saúde Pública
This paper presents an analysis of the opinions of different groups from: scientists, international regulatory bodies, non-governmental organizations and industry; with an interest in the problem of identifying chemical substances with endocrine ...
Nicolás Olea-Serrano, Mariana F. Fernández-Cabrera, Rosa Pulgar-Encinas, Fátima Olea-Serrano   +3 more
doaj  

Integrative Modeling of Urinary Metabolomics and Metal Exposure Reveals Systemic Impacts of Electronic Waste in Exposed Populations

Metabolites
Background: Informal electronic waste (e-waste) recycling practices release a complex mixture of pollutants, particularly heavy metals, into the environment.
Fiona Hui, Zhiqiang Pang, Charles Viau, Gerd U. Balcke, Julius N. Fobil, Niladri Basu, Jianguo Xia   +6 more
doaj   +1 more source

Hemimellitene (1,2,3-trimethylbenzene) in the liver, lung, kidney, and blood, and dimethylbenzoic acid isomers in the liver, lung, kidney and urine of rats after single and repeated inhalation exposure to hemimellitene

International Journal of Occupational Medicine and Environmental Health, 2016
Objectives: The aim of the study has been to explore hemimellitene distribution in blood, liver, lung and kidney as well as toxicokinetics of its elimination from blood of rats after single and repeated inhalation exposure to this compound.
Radosław Świercz, Wanda Majcherek, Wojciech Wąsowicz   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Endocrine disruptors and dental materials: health implications associated with their use in Brazil

Cadernos de Saúde Pública, 2002
This study analyzes international historical trends in the use of different types of materials in dental practice. The author describes the chemical properties of their ingredients and the potential and observed adverse effects in patients and dental ...
Coelho Antonio Jorge Molinário
doaj  

Integrating chemical structure and high-throughput transcriptomics for mechanistically interpretable Tox21 bioactivity prediction

Journal of Cheminformatics
Predictive toxicology increasingly emphasizes methods that combine scalable chemical screening with biologically interpretable mechanistic information. Existing computational approaches, however, rely largely on chemical structure alone and often fail to
Guillaume Cattebeke, Anne-Sofie Vermeersch, Davie Cappoen, Dieter Deforce, Filip Van Nieuwerburgh   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Application of chemical vapor generation systems to deliver constant gas concentrations for in vitro exposure to volatile organic compounds

Environ. Sci.: Processes Impacts, 2014
Schematic representation of the system design coupling a constant emission source from a diffusion vial to a gas phase in vitro exposure system (GIVES) for a direct air–liquid interface exposure to volatile organic compounds.
Ying-Hsuan Lin, Kenneth G. Sexton, Ilona Jaspers, Ya-Ru Li, Jason D. Surratt, William Vizuete   +5 more
openaire   +3 more sources