Results 101 to 110 of about 4,378,664 (305)

The crystal structure of 2-aminobutanamide hydrochloride, C4H11ClN2O

Zeitschrift für Kristallographie - New Crystal Structures
C4H11ClN2O, monoclinic, P21/n (no. 14), a = 4.8097(2) Å, b = 19.4142(10) Å, c = 7.8686(4) Å, β = 94.399(4)°, V = 732.58(6) Å3, Z = 4, Rgt(F) = 0.0438, wRref(F2) = 0.1308, T = 297 K.
Luan Lin, Hu Xiaowen, Zhang Caiyu, Wang Fengfeng   +3 more
doaj   +1 more source

Tolerância de mamoneira ao herbicida pendimethalin em solos com diferentes capacidades de adsorção Tolerance of castor bean to pendimethalin herbicide in soils with different adsorption capacities

Revista Brasileira de Engenharia Agrícola e Ambiental, 2012
A mamoneira é uma espécie de crescimento inicial lento. A ausência de herbicidas registrados para esta cultura, ainda é fator limitante para sua expansão; assim, objetivou-se, com este trabalho, avaliar a tolerância da mamoneira ao herbicida ...
Karoliny C. Silva, Vivianny N. B. Silva, Valdinei Sofiatti, João H. Zonta, Rosiane L. S. de Lima, Humberto Silva   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The crystal structure of (R)-2-aminobutanamide hydrochloride, C4H11ClN2O

Zeitschrift für Kristallographie - New Crystal Structures
C4H11ClN2O, orthorhombic, P212121 (no. 19), a = 4.9699(1) Å, b = 7.5867(2) Å, c = 17.3719(4) Å, V = 655.01(3) Å3, Z = 4, Rgt(F) = 0.0286, wRref(F2) = 0.0796, T = 200 K.
Wang Fengfeng, Luan Lin, Wang Youyou, Hu Xiaowen, Zhang Caiyu, Liu Yang   +5 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The crystal structure of 4-carboxy-2-oxobutan-1-aminium chloride, C5H10ClNO3

Zeitschrift für Kristallographie - New Crystal Structures
C5H10ClNO3, orthorhombic, Pbca (no. 61), a = 8.2012(1) Å, b = 11.2215(2) Å, c = 16.8339(3) Å, V = 1549.22(4) Å3, Z = 8, Rgt(F) = 0.0473, wRref(F2) = 0.1331, T = 297 K.
Wang Fengfeng, Zhang Caiyu, Wang Youyou, Luan Lin, Hu Xiaowen, Liu Yang   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source