Lactate sensing mechanisms in arterial chemoreceptor cells [PDF]
Nature Communications, 2021 Lactate levels in blood change during hypoxia or exercise, however whether this variable is sensed to evoke adaptive responses is unknown. Here the authors show that oxygen-sensing carotid body cells stimulated by hypoxia are also activated by lactate to
Hortensia Torres-Torrelo +3 more
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Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells [PDF]
Antioxidants, 2019 Carotid body (CB) chemoreceptor cells sense arterial blood PO2, generating a neurosecretory response proportional to the intensity of hypoxia. Hydrogen sulfide (H2S) is a physiological gaseous messenger that is proposed to act as an oxygen sensor in CBs,
Teresa Gallego-Martin +4 more
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Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α [PDF]
Frontiers in Physiology, 2020 Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical and chemical parameters in the blood. These cells are also essential for O2 homeostasis.
Patricia Ortega-Sáenz +10 more
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Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution [PDF]
eLifeThe opportunistic pathogen Pseudomonas aeruginosa serves as a model organism for studying multiple signal transduction pathways. The chemoreceptor cluster, a core component of the chemotaxis pathway, is assembled from hundreds of proteins.
Zhengyu Wu +5 more
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Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene [PDF]
Zoological LettersVertebrate chemoreceptor genes play a central role in detecting environmental chemical compounds through the olfactory organs and taste buds, enabling the perception of odors and tastants that are critical for survival.
Kanoko Nishiura +2 more
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Genetic map of the carotid body stem cell niche with focus on the O2-sensing chemoreceptor cell lineage [PDF]
Scientific ReportsAdaptive homeostatic responses to oxygen (O2) deficiency (hypoxia) are essential for survival. The prototypical acute O2-sensing organ is the carotid body (CB), a neural crest-derived tissue with chemoreceptor glomus cells that express hypoxia-inhibited ...
Ana Santamaría-Santiago +4 more
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Reactive Oxidative Species in Carotid Body Chemoreception: Their Role in Oxygen Sensing and Cardiorespiratory Alterations Induced by Chronic Intermittent Hypoxia [PDF]
AntioxidantsThe carotid body (CB) senses arterial PO2, PCO2, and pH levels, eliciting reflex responses to maintain cardiorespiratory homeostasis. Chronic intermittent hypoxia (CIH), the hallmark of obstructive sleep apnea, elicits autonomic and cardiorespiratory ...
Rodrigo Iturriaga, Hugo S. Diaz
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Type II Cells in the Human Carotid Body Display P2X7 Receptor and Pannexin-1 Immunoreactivity [PDF]
BiomoleculesThe carotid body is a peripheral chemoreceptor that consists of clusters of chemoreceptive type I cells, glia-like type II cells, afferent and efferent nerves, and sinusoidal capillaries and arterioles.
Marcos Anache +10 more
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Frontiers in Physiology, 2023 An interoceptive homeostatic system monitors levels of CO2/H+ and provides a proportionate drive to respiratory control networks that adjust lung ventilation to maintain physiologically appropriate levels of CO2 and rapidly regulate tissue acid-base ...
Elizabeth C. Gonye, Douglas A. Bayliss
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Vascular control of the CO2/H+-dependent drive to breathe
eLife, 2020 Respiratory chemoreceptors regulate breathing in response to changes in tissue CO2/H+. Blood flow is a fundamental determinant of tissue CO2/H+, yet little is known regarding how regulation of vascular tone in chemoreceptor regions contributes to ...
Colin M Cleary +5 more
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