Lactate sensing mechanisms in arterial chemoreceptor cells [PDF]
Nature Communications, 2021 Lactate levels in blood change during hypoxia or exercise, however whether this variable is sensed to evoke adaptive responses is unknown. Here the authors show that oxygen-sensing carotid body cells stimulated by hypoxia are also activated by lactate to
Hortensia Torres-Torrelo +3 more
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Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells [PDF]
Antioxidants, 2019 Carotid body (CB) chemoreceptor cells sense arterial blood PO2, generating a neurosecretory response proportional to the intensity of hypoxia. Hydrogen sulfide (H2S) is a physiological gaseous messenger that is proposed to act as an oxygen sensor in CBs,
Teresa Gallego-Martin +4 more
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Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body. [PDF]
Journal of General Physiology, 1989 Ionic currents of enzymatically dispersed type I and type II cells of the carotid body have been studied using the whole cell variant of the patch-clamp technique. Type II cells only have a tiny, slowly activating outward potassium current. By contrast, in every type I chemoreceptor cell studied we found (a) sodium, (b) calcium, and (c) potassium ...
Juan Ureña +2 more
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Coexpression of Galanin and Nestin in the Chemoreceptor Cells of the Human Carotid Body
Advances in Experimental Medicine and Biology, 2015 The carotid body is a highly specialized chemoreceptive organ of neural crest origin whose role is to detect changes in arterial oxygen content. The sensory units are the chemoreceptor cells, which are neuronal-like cells, surrounded by sustentacular or glial-like cells.
Andrea Mazzatenta +2 more
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Genetic map of the carotid body stem cell niche with focus on the O2-sensing chemoreceptor cell lineage [PDF]
Scientific ReportsAdaptive homeostatic responses to oxygen (O2) deficiency (hypoxia) are essential for survival. The prototypical acute O2-sensing organ is the carotid body (CB), a neural crest-derived tissue with chemoreceptor glomus cells that express hypoxia-inhibited ...
Ana Santamaría-Santiago +4 more
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Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α [PDF]
Frontiers in Physiology, 2020 Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical and chemical parameters in the blood. These cells are also essential for O2 homeostasis.
Patricia Ortega-Sáenz +10 more
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Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution [PDF]
eLifeThe opportunistic pathogen Pseudomonas aeruginosa serves as a model organism for studying multiple signal transduction pathways. The chemoreceptor cluster, a core component of the chemotaxis pathway, is assembled from hundreds of proteins.
Zhengyu Wu +5 more
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Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene [PDF]
Zoological LettersVertebrate chemoreceptor genes play a central role in detecting environmental chemical compounds through the olfactory organs and taste buds, enabling the perception of odors and tastants that are critical for survival.
Kanoko Nishiura +2 more
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Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells. [PDF]
J Physiol, 2013 Key points Arterial chemoreceptors measure blood oxygen and are involved in the control of both breathing and the cardiovascular system. Oxygen is mostly used by cells in their mitochondria to generate energy. In this study we have investigated the effects of oxygen starvation (hypoxia) on the mitochondria of specialised oxygen sensing cells from ...
Buckler KJ, Turner PJ.
europepmc +4 more sources
Reactive Oxidative Species in Carotid Body Chemoreception: Their Role in Oxygen Sensing and Cardiorespiratory Alterations Induced by Chronic Intermittent Hypoxia [PDF]
AntioxidantsThe carotid body (CB) senses arterial PO2, PCO2, and pH levels, eliciting reflex responses to maintain cardiorespiratory homeostasis. Chronic intermittent hypoxia (CIH), the hallmark of obstructive sleep apnea, elicits autonomic and cardiorespiratory ...
Rodrigo Iturriaga, Hugo S. Diaz
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