Lactate sensing mechanisms in arterial chemoreceptor cells [PDF]
Nature Communications, 2021 Lactate levels in blood change during hypoxia or exercise, however whether this variable is sensed to evoke adaptive responses is unknown. Here the authors show that oxygen-sensing carotid body cells stimulated by hypoxia are also activated by lactate to
Hortensia Torres-Torrelo +3 more
doaj +10 more sources
Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells [PDF]
Antioxidants, 2019 Carotid body (CB) chemoreceptor cells sense arterial blood PO2, generating a neurosecretory response proportional to the intensity of hypoxia. Hydrogen sulfide (H2S) is a physiological gaseous messenger that is proposed to act as an oxygen sensor in CBs,
Teresa Gallego-Martin +4 more
doaj +3 more sources
Molecular Mechanisms of Acute Oxygen Sensing by Arterial Chemoreceptor Cells. Role of Hif2α [PDF]
Frontiers in Physiology, 2020 Carotid body glomus cells are multimodal arterial chemoreceptors able to sense and integrate changes in several physical and chemical parameters in the blood. These cells are also essential for O2 homeostasis.
Patricia Ortega-Sáenz +10 more
doaj +3 more sources
Oxygen sensitivity of mitochondrial function in rat arterial chemoreceptor cells. [PDF]
J Physiol, 2013 • Arterial chemoreceptors measure blood oxygen and are involved in the control of both breathing and the cardiovascular system. • Oxygen is mostly used by cells in their mitochondria to generate energy. • In this study we have investigated the effects
Buckler KJ, Turner PJ.
europepmc +5 more sources
Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body [PDF]
The Journal of general physiology, 1989 Ionic currents of enzymatically dispersed type I and type II cells of the carotid body have been studied using the whole cell variant of the patch-clamp technique. Type II cells only have a tiny, slowly activating outward potassium current.
J. Ureña +3 more
semanticscholar +8 more sources
Potassium channel types in arterial chemoreceptor cells and their selective modulation by oxygen [PDF]
Journal of General Physiology, 1992 Single K+ channel currents were recorded in excised membrane patches from dispersed chemoreceptor cells of the rabbit carotid body under conditions that abolish current flow through Na+ and Ca2+ channels.
M. Ganfornina, J. López‐Barneo
semanticscholar +5 more sources
Mitochondrial Redox Signaling in O2-Sensing Chemoreceptor Cells
Antioxidants & Redox Signaling, 2022 Significance: Acute responses to hypoxia are essential for the survival of mammals. The carotid body (CB), the main arterial chemoreceptor, contains glomus cells with oxygen (O2)-sensitive K+ channels, which are inhibited during hypoxia to trigger ...
Lin Gao +3 more
semanticscholar +5 more sources
Spatial integration of sensory input and motor output in Pseudomonas aeruginosa chemotaxis through colocalized distribution [PDF]
eLifeThe opportunistic pathogen Pseudomonas aeruginosa serves as a model organism for studying multiple signal transduction pathways. The chemoreceptor cluster, a core component of the chemotaxis pathway, is assembled from hundreds of proteins.
Zhengyu Wu +5 more
doaj +2 more sources
Gene expression analyses reveal metabolic specifications in acute O2‐sensing chemoreceptor cells [PDF]
The Journal of Physiology, 2017 Key points Glomus cells in the carotid body (CB) and chromaffin cells in the adrenal medulla (AM) are essential for reflex cardiorespiratory adaptation to hypoxia. However, the mechanisms whereby these cells detect changes in O2 tension are poorly understood.
Lin Gao +5 more
semanticscholar +6 more sources
Genetic map of the carotid body stem cell niche with focus on the O2-sensing chemoreceptor cell lineage [PDF]
Scientific ReportsAdaptive homeostatic responses to oxygen (O2) deficiency (hypoxia) are essential for survival. The prototypical acute O2-sensing organ is the carotid body (CB), a neural crest-derived tissue with chemoreceptor glomus cells that express hypoxia-inhibited ...
Ana Santamaría-Santiago +4 more
doaj +2 more sources