Chemical Control of CRISPR Gene Editing via Conditional Diacylation Crosslinking of Guide RNAs. [PDF]
Adv Sci (Weinh), 2023 Lei H +6 more
europepmc +1 more source
Fogorvosi szemle, 1993 Most of the diseases with which dentists must deal with are related to microbial plaque and bacterial infection. The mechanical removal of supra- and subgingival plaque by the patient and by the dentist respectively, is time consuming and exacting, furthermore it is not one hundred per cent successful. There has been extensive search for many years for
openaire +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Bioactive Natural Products for Chemical Control of Microorganisms: Scientific Prospecting (2001-2021) and Systematic Review. [PDF]
Molecules, 2022 Feitosa BF +10 more
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Evaluation of the Effectiveness of Chemical Control for Chagas Disease Vectors in Loja Province, Ecuador. [PDF]
Vector Borne Zoonotic Dis, 2022 Grijalva MJ +6 more
europepmc +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Evaluation of the impact of chemical control on the ecology of Rattus norvegicus of an urban community in Salvador, Brazil. [PDF]
PLoS One, 2022 Pertile AC +14 more
europepmc +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
High-Throughput Surface Modification of Ordered Mesoporous Alumina Enables Structural Stabilization and Selective Chemical Control. [PDF]
Nanomaterials (Basel)Bindon S, Colburn TW, Dauskardt RH.
europepmc +1 more source