Results 131 to 140 of about 1,834,987 (265)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Occurrence Dynamics and Chemical Control of <i>Mycterothrips glycines</i> in Soybean Field in Northeast China. [PDF]

Insects
Zhou Y, Pei T, Li X, Zhang L, Du Z, Zhao Y, Wang L, Gao Y.   +7 more
europepmc   +1 more source

Bioactive Natural Products for Chemical Control of Microorganisms: Scientific Prospecting (2001-2021) and Systematic Review. [PDF]

Molecules, 2022
Feitosa BF, de Alcântara CM, de Lima ABS, Silva AS, Araújo ADS, Cavalcanti MT, Mori E, Araújo IM, de Farias PAM, Wilairatana P, Coutinho HDM.   +10 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Chemical Control of Ichthyotoxic Algal Blooms in Aquaculture: Assessing Algicide Impacts on Cellular Motility and Bloom Suppression. [PDF]

Microorganisms
Mehdizadeh Allaf M, Yi T, Zhang J, Zhang S, Erratt KJ, Dehnavi P, Peerhossaini H.   +6 more
europepmc   +1 more source

Evaluation of the Effectiveness of Chemical Control for Chagas Disease Vectors in Loja Province, Ecuador. [PDF]

Vector Borne Zoonotic Dis, 2022
Grijalva MJ, Villacís AG, Ocaña-Mayorga S, Yumiseva CA, Nieto-Sanchez C, Baus EG, Moncayo AL.   +6 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Evaluation of the impact of chemical control on the ecology of Rattus norvegicus of an urban community in Salvador, Brazil. [PDF]

PLoS One, 2022
Pertile AC, Lustosa R, Carvalho-Pereira T, Pedra GG, Panti-May JA, Oliveira U, Zeppelini CG, Souza FN, Oliveira DS, Khalil H, Reis MG, Childs J, Ko AI, Begon M, Costa F.   +14 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Non-chemical control of fungal pathogens in crops: a one-health perspective on strategies, mechanisms, and future directions. [PDF]

Front Plant Sci
Adkar-Purushothama CR, Chettimada A, Murali TS, Muthusamy A, Bouarab K, Perreault JP.   +5 more
europepmc   +1 more source