Results 131 to 140 of about 1,693,931 (265)

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Potential of Essential Oils and Major EO Constituents in the Chemical Control of <i>Spodoptera frugiperda</i>. [PDF]

Plants (Basel)
Usseglio VL, Beato M, Dambolena JS, Zunino MP.   +3 more
europepmc   +1 more source

Response of faba bean to intercropping, biological and chemical control against broomrape and root rot diseases. [PDF]

Saudi J Biol Sci, 2022
El-Mehy AA, El-Gendy HM, Aioub AAA, Mahmoud SF, Abdel-Gawad S, Elesawy AE, Elnahal ASM.   +6 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Identification and Chemical Control of Stem Canker Pathogen of <i>Idesia polycarpa</i>. [PDF]

Plants (Basel)
Feng J, Yuan Q, Chen X, Fang L, Zhang T, Liu Z, Wang Y, Geng X, Cai Q, Li Z.   +9 more
europepmc   +1 more source

Dual electrochemical and chemical control in atom transfer radical polymerization with copper electrodes. [PDF]

Chem Sci, 2022
De Bon F, Lorandi F, Coelho JFJ, Serra AC, Matyjaszewski K, Isse AA.   +5 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Chemical control of colloidal self-assembly driven by the electrosolvation force. [PDF]

Nat Commun
Wang S, Walker-Gibbons R, Watkins B, Lin B, Krishnan M.   +4 more
europepmc   +1 more source

Effect of the combination of biological, chemical control and agronomic technique in integrated management pea root rot and its productivity. [PDF]

Sci Rep, 2022
Nazir N, Badri ZA, Bhat NA, Bhat FA, Sultan P, Bhat TA, Rather MA, Sakina A.   +7 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source