Results 131 to 140 of about 4,446,617 (245)

N‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary Sulfonimidamides

Angewandte Chemie, EarlyView.
N‐Alkoxysulfurdiimide reagents when combined with organometallic reagents lead directly to primary sulfonimidamide products. The reactions are broad in scope, encompassing aryl, heteroaryl, and alkyl carbon substituents. The reactivity of the N‐alkoxysulfurdiimide reagents can be correlated with the electron‐withdrawing ability of the N‐substituent ...
Suzanne E. Davison, Jonathan A. Andrews, Agamemnon E. Crumpton, Mireia Sidera Portela, Michael A. Clegg, Damien Valette, Michael C. Willis   +6 more
wiley   +2 more sources

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

Enhancing Enzyme Activity With Mutation Combinations Guided by Few‐Shot Learning and Causal Inference

Angewandte Chemie, EarlyView.
We present an integrated workflow that predicts activity‐enhancing mutation combinations from minimal experimental data. By proposing in vivo unit yield (yield/expression) as a surrogate for kcat/Km through causal inference, and visualizing local activity landscape, it effectively guides product yield improvement. ABSTRACT Designing enzyme sequences to
Lin Guo, Xiaoguang Yan, Yali Lu, Shengxin Nie, Mingyue Ge, Yukun Li, Weiguo Li, Xiaochun Zhang, Dongmei Liang, Yihan Zhao, Hongxiao Tan, Xiling Chen, Shilong Fan, Yefeng Tang, Jianjun Qiao, Boxue Tian   +15 more
wiley   +2 more sources

Serial Chemical Crystallography for Autonomous Quantitative Phase Analysis in an Electron Microscope. [PDF]

Small Methods
Yang T, Waterman DG, Chu Z, Beilsten-Edmands J, Huang Z, Zou X.   +5 more
europepmc   +1 more source

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Organocatalytic Enantioselective Addition of Malonates to Cyclic Imines: A Short Total Synthesis of Tetraponerine T‐1

Angewandte Chemie, EarlyView.
A stereoselective functionalization method of cyclic imines under mild organocatalytic conditions was developed. Bifunctional cinchona alkaloid catalysts combined with carefully optimized reaction conditions to suppress background reactivity enabled highly enantio‐ and diastereoselective addition reactions of malonates to cyclic imines.
Frederic Kölblin, Helma Wennemers
wiley   +2 more sources

How to use DIALS to process chemical crystallography 3D ED rotation data from pixel array detectors. [PDF]

Acta Crystallogr C Struct Chem
Vypritskaia A, Zou X, Yang T, Waterman DG.   +3 more
europepmc   +1 more source

A Multi‐Stimuli Transformational Network of Benzil‐Based Pd(II) Assemblies

Angewandte Chemie, EarlyView.
Incorporation of a flexible and chemically reactive benzil backbone into the ligand structure allows it to access multiple conformations, enabling the formation of diverse homo‐ and heteroleptic Pd(II) assemblies with different nuclearities and topologies.
Zhiwei Zeng, A. Priscila Gia, Alexander S. Mikherdov, Mert Acar, Björn Schmidt, Guido H. Clever   +5 more
wiley   +2 more sources

Dual Activation of H2 and CO2 by a Pincer‐Type Ni–Zn Heterobimetallic Complex

Angewandte Chemie, EarlyView.
A bimetallic Ni−Zn complex performs sequential activations of H2 (1 equiv) and CO2 (2 equiv). This bimetallic cooperativity is attributed to the weak Lewis acidic nature of Zn(II), which promotes fluxional ligand binding. Namely, an X‐type ligand at Ni, where X is hydride or formate, toggles between two different binding modes: bridging Zn(μ‐X)Ni and ...
Krishnendu Dey, Matthias Borowski, Gregor Schnakenburg, Connie C. Lu   +3 more
wiley   +2 more sources

A Blue Emissive Heavy Atom‐Free Multiresonant Thermally Activated Delayed Fluorescent Emitter Shows Ultra‐Fast Reverse Intersystem Crossing

Angewandte Chemie, EarlyView.
The extended π‐system and low‐lying n‐π∗ transition endow DDOBDiKTa with a synergistic combination of strong spin‐orbit coupling, small reorganization energy and small ΔEST, enabling this blue boron‐nitrogen‐carbonyl hybrid emitter to achieve a fast kRISC of 6.34 × 106 s−1 together with OLEDs showing small efficiency roll‐off, with EQEmax/EQE10000 of ...
Wenrui Wang, Hassan Hafeez, Sen Wu, Aidan P. McKay, David B. Cordes, Ifor D. W. Samuel, Eli Zysman‐Colman   +6 more
wiley   +2 more sources