Results 161 to 170 of about 3,897,550 (347)

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

Advanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, Hanjun Zhao, Kang Zhang, Shilong Fan, Yuanchen Dong, Dongsheng Liu, Xinquan Wang, Deli Huang, Xiaojing Pan, Chunying Chen, Zhihua Liu, Li‐Tang Yan, Qi Zhang, Linqi Zhang, Yuliang Zhao, Yuhe Renee Yang   +29 more
wiley   +1 more source

Isolation and X-ray Structures of Labile Benzoic- and Acetic-Acidium Carbocations [PDF]

, 2005
New carbocationic salts (via O-protonation of substituted benzoic acids) are prepared for the first time by controlled hydration of the corresponding benzoylium salts and isolated in pure crystalline form.
Davlieva, M. G., Kochi, Jay K., Lindeman, Sergey V., Neretin, I. S.   +3 more
core   +1 more source

NMR Crystallography of Campho[2,3-c]pyrazole (Z′ = 6): Combining High-Resolution ¹H-¹³C Solid-State MAS NMR Spectroscopy and GIPAW Chemical-Shift Calculations

, 2010
Amy L. Webber, Lyndon Emsley, Rosa M. Claramunt, Steven P. Brown   +3 more
openalex   +2 more sources

Cryo‐EM Structures Reveal the Molecular Basis of Asymmetric Allosteric Activation by MMOB in the Hydroxylase of Soluble Methane Monooxygenase

Advanced Science, EarlyView.
Cryo‐EM analysis reveals an asymmetric MMOH–MMOB complex with distinct protomers, where MMOB binding triggers structural rearrangements from the surface to the active site. This conformational asymmetry shortens the Fe···Fe distance to 2.7 Å in one protomer, forming a geometry suitable for O2 activation and supporting a sequential catalytic mechanism ...
Yunha Hwang, Bumhan Ryu, Soyeon Park, Dong‐Heon Lee, Hyo Jin Hong, Jeong‐Geol Na, Chul Gyu Song, Hyun Goo Kang, Edwin Pozharski, Seung Jae Lee   +9 more
wiley   +1 more source

Multinuclear Solid-State Magnetic Resonance Studies on ‘Exotic’ Quadrupolar Nuclei: Acquisition Methods, High-Order Effects, Quantum Chemical Computations, and NMR Crystallography

, 2012
Cory M. Widdifield
openalex   +1 more source

A new high-flux chemical and materials crystallography station at the SRS Daresbury. 1. Design, construction and test results. Corrigendum [PDF]

, 2000
Robert J. Cernik, W. Clegg, C. Richard A. Catlow, G. Bushnell-Wye, J. V. Flaherty, G. Neville Greaves, I. Burrows, David J. Taylor, Simon J. Teat, Mohammed Hamichi   +9 more
openalex   +1 more source

Chemical annotation in the Crystallography Open Database [PDF]

, 2021
Andrius Merkys, Antanas Vaitkus, A. Grybauskas, Aleksandras Konovalovas, Miguel Quirós Olozábal, S. Gražulis   +5 more
openalex   +1 more source

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

Advanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang, Wenkai Wang, Zhenling Peng, Jianyi Yang   +3 more
wiley   +1 more source

Pushing the limits of microfocus X-ray sealed-tube sources for biological and chemical crystallography [PDF]

, 2020
J. Graf, Tobias Stuerzer, Matthew M. Benning, Holger Ott, P. Radcliffe, J. Schmidt-May, Carsten Michaelsen   +6 more
openalex   +1 more source

Photochromism‐Driven Full Solar Spectrum Absorption for Efficient Photo‐Thermo‐Electric Conversion

Advanced Science, EarlyView.
After electron‐transfer photochromism, a black viologen‐based organic compound shows full solar spectrum absorption (250–2500 nm) and near‐infrared photothermal conversion efficiency (NIR‐PCE) >60%. Integrated with a thermoelectric generator, it outputs 1.17 V under 4 Suns irradiation, enough to drive a small fan via photo‐thermo‐electric conversion ...
Ning‐Ning Zhang, Lin‐Xu Liu, Zhen‐Yu Li, Yong‐Fang Han, Wen‐Wen Zi, Kong‐Gang Qu, Ming‐Sheng Wang, Yong Yan   +7 more
wiley   +1 more source