Results 41 to 50 of about 49,135 (303)

Possibilities of Developing Medical Support Capabilities in the Area of Chemical, Biological Radiological and Nuclear Defence

, 2023
The article deals with the evaluation of current possibilities of medical support capabilities in the area of Chemical, Biological, Radiological and Nuclear Defence.
Richard Saibert, Aleš Tichý
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Survival and persistence of Nipah virus in blood and tissue culture media

Emerging Microbes and Infections, 2019
Nipah virus (NiV) infection is a newly emerging zoonosis that causes severe disease in humans. Nipah virus is one of the lesser studied of the WHO emerging pathogens for which research is a priority.
Sophie J. Smither, Lin S. Eastaugh, James S. Findlay, Lyn M. O’Brien, Ruth Thom, Mark S. Lever   +5 more
doaj   +1 more source

Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice

Toxics, 2022
The therapeutic efficacy of treatments for acute intoxication with highly toxic organophosphorus compounds, called nerve agents, usually involves determination of LD50 values 24 h after nerve agent challenge without and with a single administration of ...
Jiri Kassa, Christopher M. Timperley, Mike Bird, A. Christopher Green, John E. H. Tattersall   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Chemical Protection Studies of Activated Carbon Spheres based Permeable Protective Clothing Against Sulfur Mustard, a Chemical Warfare Agent

, 2019
Technological advancements in the field of chemical threat have made it possible to create extremely dangerous chemical warfare agents (CWA). Hence, the effective protection of personnel is very important in a chemical warfare scenario amidst the ...
Singh, Virendra K., Sharma, Pushpendra K., Verma, Vijay, Gupta, Arvind Kumar, Chaturvedi, Ajay, Acharya, Jyotiranjan, Tripathi, Nagesh K., Ganesan, K., Sharma, Shiv Prakash, Tomar, L.N. S., Thakare, Vikas B., Sathe, Manisha, Yadav, S. S.   +12 more
core   +1 more source

Molecular basis of the explosive defence response in the bombardier beetle Brachinus crepitans

Royal Society Open Science
Bombardier beetles have evolved a sophisticated and unique chemical defence mechanism involving controlled explosions within their paired defensive glands, producing a hot, benzoquinone-rich defensive spray.
Heiko Vogel, Nicolai Rügen, Natalie Wielsch, Richard M. Twyman, Miray Tonk-Rügen, Andreas Vilcinskas   +5 more
doaj   +1 more source

An Enzyme-Based Biosensor for the Detection of Organophosphate Compounds Using Mutant Phosphotriesterase Immobilized onto Reduced Graphene Oxide

Journal of Chemistry, 2021
Enzymatic detection of organophosphate (OP) compounds can be tailored using highly sensitive and selective enzymes in the development of biosensors.
Muhammad Syafiq Mohd Razib, Wahhida Latip, Jahwarhar Izuan Abdul Rashid, Victor Feizal Knight, Wan Md Zin Wan Yunus, Keat Khim Ong, Noor Azilah Mohd Kasim, Siti Aminah Mohd Noor   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Nano-Magnetic Immunosensor Based on Staphylococcus Protein A and the Amplification Effect of HRP-Conjugated Phage Antibody

Sensors, 2015
In this research, super-paramagnetic Fe3O4 nanoparticles (magnetic particles) were coated with Staphylococcus protein A (SPA) and coupled with polyclonal antibody (pcAb) to construct magnetic capturing probes, and HRP-conjugated phage antibody was then ...
Xihui Mu, Zhaoyang Tong, Qibin Huang, Bing Liu, Zhiwei Liu, Lanqun Hao, Jinping Zhang, Chuan Gao, Fenwei Wang   +8 more
doaj   +1 more source