Results 91 to 100 of about 4,478,531 (313)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Defenses of whirligig beetles against native and invasive frogs [PDF]
PeerJMany native insects have evolved defenses against native predators. However, their defenses may not protect them from non-native predators due to a limited shared history.
Shinji Sugiura, Masakazu Hayashi
doaj +2 more sources
Scientific Reports, 2021 If optimal investment in anti-predator defences depends on predation risk, invading new regions (and thus, encountering different predators) may favour shifts in that investment.
Cameron M. Hudson +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Pollen-feeding delays reproductive senescence and maintains toxicity of Heliconius erato
Peer Community JournalDietary shifts may act to ease energetic constraints and allow organisms to optimise life-history traits. Heliconius butterflies differ from other nectar-feeders due to their unique ability to digest pollen, which provides a reliable source of amino ...
Pinheiro de Castro, Erika C. +6 more
doaj +1 more source
Costs and benefits of chemical defence in the Red Alga Bonnemaisonia hamifera.
PLoS ONE, 2013 A number of studies have shown that the production of chemical defences is costly in terrestrial vascular plants. However, these studies do not necessarily reflect the costs of defence production in macroalgae, due to structural and functional ...
Göran M Nylund +2 more
doaj +1 more source
Amathamide alkaloids in the pycnogonid, Stylopallene longicauda, epizoic on the chemically defended bryozoan, Amathia wilsoni [PDF]
, 1998 Amathamides comprise a group of brominated alkaloids found in the bryozoan, Amathia wilsoni Kirkpatrick (Gymnolaemata: Ctenostomata). We tested a crude bryozoan extract and purified amathamide C for their ability to deter feeding by fish, Acanthaluteres ...
Ritz, DA, Sherwood, J, Walls, JT
core +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Secretory laccase 1 in Bemisia tabaci MED is involved in whitefly-plant interaction
Scientific Reports, 2017 The whitefly Bemisia tabaci is a phloem-feeding pest that lives predominantly on herbaceous species and causes serious damage to hosts. Whitefly saliva is thought to contain proteins that modulate plant defences and facilitate feeding.
Chun-Hong Yang +6 more
doaj +1 more source