Results 101 to 110 of about 125,120,791 (279)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Swelling, mass transport, and chemical kinetics in bituminous coal pyrolysis [PDF]
, 1989 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1989.Includes bibliographical references (leaves 330-340).by Jaanpyng Hsu.Ph ...
Hsu, Jaanpyng
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Chemical and Biological Microsystems - What Are the Advantages of Small Systems?
, 2010 The 25th annual Ashton Cary Lecture was presented on April 14, 2010 from 4-5 pm in room G011 of the Molecular Science and Engineering Building on the Georgia Tech Campus.The Cary Lecture SeriesMicrofabrication techniques have fueled spectacular advances ...
Jensen, Klavs F.
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Independent Development Strategy of High-Performance Polymers
中国工程科学High-performance polymers have become a strategic material to ensure national security and national economic development owing to their excellent comprehensive properties.
Xia Yuqing +9 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Modelling of transport processes in chemical vapor deposition reactors
, 1989 Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1989.Science hard copy bound in 2 v.Includes bibliographical references (leaves 316-328).by Sanjay Patnaik.Ph ...
Patnaik, Sanjay
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source