Results 121 to 130 of about 349,954 (287)

A novel bioactive nano-composite: synthesis and characterisation with potential use as dental restorative material

, 2009
PhDIt is desirable for a dental restorative material to have bioactive and bonding properties. This study focuses on the synthesis of a covalently-linked polyurethane/nanohydroxyapatite (PU/nHA) composite and evaluates its chemical, physical, thermal ...
Khan, Abdul Samad
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Modelagem e simulação da emissão de material particulado a partir da queima de bagaço em uma usina de açúcar e álcool [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2013.A proposta deste trabalho é a modelagem fenomenológica de uma chaminé expelindo material particulado
Avelar, Felipe Del Mônaco dos Santos Lopes de
core  

Production Of Butanol And Other High Valued Chemicals Using Ethanol As Feedstock Integrated To A First And Second Generation Sugarcane Distillery

, 2015
Production of chemicals and second generation ethanol from lignocellulosic material integrated to first generation sugarcane biorefineries presents potential for industrial implementation, since significant part of the infrastructure may be shared ...
Cavalett O., Chagas M.F., Pereira L.G., Dias M.O.S., Junqueira T.L., Filho R.M., Bonomi A.   +6 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Interfacial instabilities: implications for multi-material moulding [PDF]

This work investigates and identifies the mechanisms that are at work in the creation of instabilities during co-injection moulding. Two aspects are investigated, neither of which has been previously reported.
Goodship, Vannessa
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Chemical inhibition of asexual development leads to increased ultimate tensile strength in mycelial material

This study investigates the chemical inhibition of asexual development in Aspergillus nidulans to enhance the mechanical properties of mycelial materials.
Lee, JungHun, Doan, Alexander G., Huso, Walker, Edwards, Harley, Folmer, Ethan, Lawrence, Ololade, Gray, Kelsey, Marten, Mark, Harris, Steven D.   +8 more
core   +1 more source