Results 131 to 140 of about 349,954 (287)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Research Progress on Nanopolymer Composites in Civil Engineering
NanomaterialsCivil engineering infrastructure suffers material degradation, shortened service life and high maintenance costs under harsh environments and natural aging, threatening public safety.
Tingting Gao +3 more
doaj +1 more source
Development of a combined catalyst and sorbent for the water gas shift reaction
, 2014 A combined catalyst and sorbent was developed for reacting CO with steam to produce H2 in a single reaction stage at 600 °C by employing the water gas shift (WGS) reaction.
Albrecht, Karl +3 more
core
Laser-induced in-fiber capillary instability and material engineering
, 2019 The emerging of multimaterial fibers has been found with widespread applications in various areas. Towards the concept, preform-to-fiber thermal drawing method has been well-established which allows the fabrications of glass or polymer-based fibers with ...
Zhang, Jing
core +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Bioinspired hierarchical structures for superhydrophobic polyethylene
eXPRESS Polymer LettersInspired by natural structures, this study successfully developed innovative composites through the strategic integration of biomimetic concepts and advanced material engineering techniques.
Shuang Gao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Biosurface and BiotribologyDue to trauma and disease, bone defects endanger the healthy life of human beings. At present, the gold standard for bone defect repair is still autologous bone transplantation and allogeneic bone transplantation.
Guowen Duan +9 more
doaj +1 more source