Results 151 to 160 of about 596,259 (322)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Chemical Diagnostics to Unveil Environments Enriched by First Stars
The Astrophysical Journal LettersUnveiling the chemical fingerprints of the first (Population III, hereafter Pop III) stars is crucial for indirectly studying their properties and probing their massive nature.
Irene Vanni +4 more
doaj +1 more source
Simultaneous Quantitation of Glycoprotein Degradation and Synthesis Rates by Integrating Isotope Labeling, Chemical Enrichment, and Multiplexed Proteomics. [PDF]
Anal Chem, 2017 Xiao H, Wu R.
europepmc +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
BiNChE: a web tool and library for chemical enrichment analysis based on the ChEBI ontology. [PDF]
BMC Bioinformatics, 2015 Moreno P +11 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Chemoproteomics, A Broad Avenue to Target Deconvolution
Advanced ScienceAs a vital project of forward chemical genetic research, target deconvolution aims to identify the molecular targets of an active hit compound.
Yihui Gao +3 more
doaj +1 more source
Physico-chemical Properties of Corn Extrudates Enriched with Tomato Powder and Ascorbic Acid
, 2015 Valentina Obradović
openalex +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source