Results 221 to 230 of about 596,259 (322)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Genetic insights and mechanistic parallels in gestational diabetes mellitus and type 2 diabetes. [PDF]

Nat Commun
Fu L, Han X, Wang Y, Hu YQ.
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Transcriptomic and metabolomic analysis of tobacco responses to combined organic-chemical fertilization. [PDF]

BMC Plant Biol
Zhang X, Liang K, Dong M, Ma X, Sun F, Wang Z, Ye X.   +6 more
europepmc   +1 more source

Effect of compost and chemical fertilizers on microbial biomass phosphorus. (T₁: control; T₂: 100% RDF; T₃: enriched compost; T₄: 100% RDF + enriched compost; T₅: 50% RDF + enriched compost). * The least significant difference test for separation of means indicates that means that are separated by the same letter are not significantly distinct at P = 0.05.

Dilkhush Meena (21473985), Murli Dhar Meena (18864501), Satendra Singh Sengar (21473988), Vidhya Nand Mishra (21473991), Anup Kumar (1391461), Mohan Lal Lakhera (21473994), Mohan Lal Dotaniya (9727737), Mukesh Kumar Meena (11287133), Sujith Kumar (21473997), Bheeru Lal Meena (18864513), Ram Swaroop Jat (18864504), Lalit Krishan Meena (21474000), Mukesh Prajapat (21474003), Hari Singh Meena (18864510), Avijit Ghosh (1428496), Vasudev Meena (14312365), Pramod Kumar Rai (18864516), Parvender Sheoran (14703865), Vijay Singh Meena (20564213)   +18 more
openalex   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

The possibility of prognostic and functional values of the 8q24 and 20q13 chromosomal bands in colorectal cancer. [PDF]

Mol Biol Res Commun
Siadat SA.
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source