Results 251 to 260 of about 596,259 (322)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Pharmacophore modeling: advances and pitfalls. [PDF]

Front Mol Biosci
Elsaka MY, Taha MM, Tayel A, Tawfik HO, Ibrahim MAA, Shoeib T.   +5 more
europepmc   +1 more source

Enrichment of the high school chemistry course through projects in chemical applications

, 1931
Charles A Wallace
openalex   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Early chemical enrichment of the Milky Way dwarf satellites from high-resolution and NLTE analysis of VMP stars

, 2018
L. Mashonkina, P. Jablonka, T. Sitnova, Yuri Pakhomov, P. North, А. М. Татарников, М. А. Бурлак, O. V. Vozyakova   +7 more
openalex   +2 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Exploring the mechanism of plasticizers action in liver damage based on network toxicology, molecular docking, and molecular dynamic simulation. [PDF]

Sci Rep
Feng C, Chun L, KeLei S, XiaoGuang T, HouHong W, YongYun C, MengLei X, Bin L.   +7 more
europepmc   +1 more source

Mass-dependent chemical enrichment sequences of SDSS star-forming galaxies out to z~0.3 revealed by direct O & Ar abundances [PDF]

Souradeep Bhattacharya, M. Arnaboldi, Chiaki Kobayashi, Ortwin Gerhard, Kanak Saha   +4 more
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source