Results 261 to 270 of about 596,259 (322)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Phenotypically anchored transcriptomics across diverse agrichemicals reveals conserved pathways and unique gene expression signatures in zebrafish. [PDF]

Front Toxicol
St Mary L, McClure R, Truong L, Carrell SJ, Waters KM, Tanguay RL.   +5 more
europepmc   +1 more source

Science Ready Spectra Of Star Clusters And Their Best-Fitting Models Described In The Research Paper "Using Star Clusters As Tracers Of Star Formation And Chemical Evolution: The Chemical Enrichment History Of The Large Magellanic Cloud" By Chilingarian & Asa'D

, 2018
Igor Chilingarian
openalex   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Enrichment Characteristics and Genetic Analysis of Rare Earth Elements in the Lower Longtan Formation Coal of Qianbei Coalfield, Guizhou Province. [PDF]

ACS Omega
Li Y, Zhu Y, Yang Z, Wang F, Ding Y, Li B, Yang Y, Hu C.   +7 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Multi-targeted inhibition of NF-κB signaling underlies the anti-osteoarthritic effects of BGJXF and its key component dehydrocorydaline. [PDF]

Front Med (Lausanne)
Shen J, Bin Z, Shen Y, Xie F, Zhang X, Tan X, Xu H.   +6 more
europepmc   +1 more source

Changes in total-P, inorganic-P and organic-P fractions as affected with compost and chemical fertilizers. (T1: control; T2: 100% RDF; T3: enriched compost; T4: 100% RDF + enriched compost; T5: 50% RDF + enriched compost). * The least significant difference test for separation of means indicates that means that are separated by the same letter are not significantly distinct at P = 0.05.

Dilkhush Meena (21473985), Murli Dhar Meena (18864501), Satendra Singh Sengar (21473988), Vidhya Nand Mishra (21473991), Anup Kumar (1391461), Mohan Lal Lakhera (21473994), Mohan Lal Dotaniya (9727737), Mukesh Kumar Meena (11287133), Sujith Kumar (21473997), Bheeru Lal Meena (18864513), Ram Swaroop Jat (18864504), Lalit Krishan Meena (21474000), Mukesh Prajapat (21474003), Hari Singh Meena (18864510), Avijit Ghosh (1428496), Vasudev Meena (14312365), Pramod Kumar Rai (18864516), Parvender Sheoran (14703865), Vijay Singh Meena (20564213)   +18 more
openalex   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source