Results 101 to 110 of about 1,651,742 (317)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Discharge plasma for prebiotic chemistry: Pathways to life’s building blocks

Earth and Planetary Physics
Discharge plasmas, recognized as unique platforms for investigating the origins of chemical life, have garnered extensive interest for their potential to simulate prebiotic conditions. This paper embarks on a comprehensive overview of recent advancements
DingWei Gan, LongFei Hong, TianYu Li, TianQi Zhang, XiangYu Wang, JiePing Fan, RuSen Zhou, DingXin Liu, JianXi Ying, Patrick J. Cullen, YuFen Zhao, RenWu Zhou   +11 more
doaj   +1 more source

The Chemical Evolution of the Milky Way

, 1999
The field of chemical evolution modeling of the Galaxy is experiencing in the last years a phase of high activity and important achievements. There are, however, several open questions which still need to be answered. In this review I summarize what have
A Pasquali, A Renzini, AA Penzias, AI Boothroyd, B Barbuy, B Edvardsson, C Chiappini, CG Lacey, E Anders, F Matteucci, Forestini, JM Scalo, LB van den Hoek, M Tosi, M Tosi, M Tosi, M Tosi, N Prantzos, P Kroupa, PA Shaver, R Wielen, Rocha, S Boissier, S Smartt, SE Woosley, T.C. Beers, WJ Maciel, WJ Maciel   +27 more
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Chemical Evolution Reimagined

, 2022
Some of the most interesting open questions about the origins of life and molecular sciences center on chemical evolution and the spontaneous generation of new complex and functional chemical species. The spectacular polymers that underlay biology demonstrate an untapped, by modern science, creative potential.
Moran Frenkel Pinter, Kavita Matange, Vahab Rajaei, John T Costner, Adelaide Robertson, Jennifer Seoyoung Kim, Anton S Petrov, Jessica C. Bowman, Loren Dean Williams   +8 more
openaire   +1 more source

Chemical enrichment of galaxy clusters from hydrodynamical simulations

, 2007
We present cosmological hydrodynamical simulations of galaxy clusters aimed at studying the process of metal enrichment of the intra--cluster medium (ICM).
Arimoto, Balestra, Bate, Baumgartner, Bertelli, Borgani, Cen, Chiappini, Chiappini, Chieffi, Cora, Dalla Vecchia, Davé, De Grandi, De Lucia, Dolag, Domainko, F. Matteucci, Finoguenov, Finoguenov, François, Gal-Yam, Gal-Yam, Gastaldello, Gibson, Greggio, Haardt, Iwamoto, K. Dolag, Katz, Kawata, Kay, Kennicutt, Kobayashi, Kroupa, L. Tornatore, Larson, Lia, Loewenstein, Maeder, Maoz, Marigo, Matteucci, Matteucci, Matteucci, Matteucci, Matteucci, Mazzotta, Monaco, Mosconi, Murante, Mushotzky, Nagashima, Navarro, Padovani, Pipino, Portinari, Portinari, Raiteri, Rasia, Rasia, Rebusco, Recchi, Renzini, Renzini, Renzini, Roediger, Romano, Romeo, Rosati, S. Borgani, Salpeter, Samland, Sarazin, Saro, Scalo, Scannapieco, Scannapieco, Schmidt, Sijacki, Sijacki, Sommer-Larsen, Springel, Springel, Springel, Springel, Springel, Springel, Strickland, Sutherland, Tamura, Theis, Thielemann, Tormen, Tornatore, Tutukov, Valdarnini, Van Den Hoek, Vikhlinin, Vikhlinin, Voit, Woosley, Yoshikawa   +102 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Morphological Evolution of Vertically Standing Molybdenum Disulfide Nanosheets by Chemical Vapor Deposition [PDF]

, 2018
Song Zhang, Jiajia Liu, Karla Hernández Ruíz, Rong Tu, Meijun Yang, Qizhong Li, Ji Shi, Haiwen Li, Lianmeng Zhang, Takashi Goto   +9 more
openalex   +1 more source

Galactic Chemical Evolution

, 2016
We analyze the evolution of oxygen abundance radial gradients resulting from our chemical evolution models calculated with different prescriptions for the star formation rate (SFR) and for the gas infall rate, in order to assess their respective roles in shaping gradients.
Gibson, Brad K., Cavichia, Oscar, Costa, Roberto Dell’Aglio Dias da, Díaz, Ángeles I., Mollá, Mercedes   +4 more
openaire   +2 more sources