Results 101 to 110 of about 1,642,984 (314)

Discharge plasma for prebiotic chemistry: Pathways to life’s building blocks

Earth and Planetary Physics
Discharge plasmas, recognized as unique platforms for investigating the origins of chemical life, have garnered extensive interest for their potential to simulate prebiotic conditions. This paper embarks on a comprehensive overview of recent advancements
DingWei Gan, LongFei Hong, TianYu Li, TianQi Zhang, XiangYu Wang, JiePing Fan, RuSen Zhou, DingXin Liu, JianXi Ying, Patrick J. Cullen, YuFen Zhao, RenWu Zhou   +11 more
doaj   +1 more source

$\mathit{Chempy}$: A flexible chemical evolution model for abundance fitting - Do the Sun's abundances alone constrain chemical evolution models?

, 2017
Elemental abundances of stars are the result of the complex enrichment history of their galaxy. Interpretation of observed abundances requires flexible modeling tools to explore and quantify the information about Galactic chemical evolution (GCE) stored ...
Just, Andreas, Rix, Hans-Walter, Rybizki, Jan   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

The Chemical Evolution of the Milky Way

, 1999
The field of chemical evolution modeling of the Galaxy is experiencing in the last years a phase of high activity and important achievements. There are, however, several open questions which still need to be answered. In this review I summarize what have
A Pasquali, A Renzini, AA Penzias, AI Boothroyd, B Barbuy, B Edvardsson, C Chiappini, CG Lacey, E Anders, F Matteucci, Forestini, JM Scalo, LB van den Hoek, M Tosi, M Tosi, M Tosi, M Tosi, N Prantzos, P Kroupa, PA Shaver, R Wielen, Rocha, S Boissier, S Smartt, SE Woosley, T.C. Beers, WJ Maciel, WJ Maciel   +27 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Chemical Evolution Reimagined

, 2022
Some of the most interesting open questions about the origins of life and molecular sciences center on chemical evolution and the spontaneous generation of new complex and functional chemical species. The spectacular polymers that underlay biology demonstrate an untapped, by modern science, creative potential.
Moran Frenkel Pinter, Kavita Matange, Vahab Rajaei, John T Costner, Adelaide Robertson, Jennifer Seoyoung Kim, Anton S Petrov, Jessica C. Bowman, Loren Dean Williams   +8 more
openaire   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Galactic Chemical Evolution

, 2016
We analyze the evolution of oxygen abundance radial gradients resulting from our chemical evolution models calculated with different prescriptions for the star formation rate (SFR) and for the gas infall rate, in order to assess their respective roles in shaping gradients.
Gibson, Brad K., Cavichia, Oscar, Costa, Roberto Dell’Aglio Dias da, Díaz, Ángeles I., Mollá, Mercedes   +4 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Is Life an Unavoidable Consequence of the Formation of the Universe? Investigating the Formation of Bio-Precursors and the Signature of Earth-Like Living Forms

Frontiers in Astronomy and Space Sciences, 2018
This contribution to the Research Topic “Imagining the Future of Astronomy and Space Sciences” focuses on astrobiology and exoplanetary research. Understanding the origin of life is the main scientific challenge to this century and an interdisciplinary ...
Ana I. Gomez de Castro
doaj   +1 more source