Results 121 to 130 of about 389,444 (301)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Ryugu asteroid sample return provides a natural laboratory for primordial chemical evolution. [PDF]

Nat Commun, 2023
Oba Y, Takano Y, Dworkin JP, Naraoka H.
europepmc   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Stellar Abundance Analyses: Constraints on Nucleosynthesis and Chemical Evolution?

, 2007
Recent advances in the determination of stellar abundances and their impact on the study of nucleosynthesis and the chemical evolution of galaxies are discussed.
C. Abia
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

CHemical Evolution in MassIve star-forming COres (CHEMICO)

Context. Increasing evidence shows that most stars in the Milky Way, including the Sun, are born in star-forming regions that also contain high-mass stars. However, due to both observational and theoretical challenges, our understanding of their chemical
Bizzocchi, L., Caselli, P., Vasyunin, A., Á. Lopez-Gallifa, H. Martín-Caballero, L. Colzi, P. Caselli, Martín-Caballero, H., V. M. Rivilla, E. Roueff, C. Mininni, A. Vasyunin, Colzi, L., Fontani, F., Roueff, E., Mininni, C., Rivilla, V. M., Beltrán, M. T., F. Fontani, L. Bizzocchi, Lopez-Gallifa, Á., M. T. Beltrán   +21 more
core   +1 more source

Chemical Evolution of Natural Product Structure. [PDF]

J Am Chem Soc, 2022
Grigalunas M, Brakmann S, Waldmann H.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Chemical evolution and galaxy formation

, 2002
Following a review of the basic ingredients necessary for constructing models of galactic chemical evolution, with a special emphasis on the issue of stellar evolution and nucleosynthesis (which is treated in detail in Chapter 2), I continue with the ...
Romano, Donatella
core  

Evolution at the Origins of Life?

Life
The role of evolutionary theory at the origin of life is an extensively debated topic. The origin and early development of life is usually separated into a prebiotic phase and a protocellular phase, ultimately leading to the Last Universal Common ...
Ludo L. J. Schoenmakers, Thomas A. C. Reydon, Andreas Kirschning   +2 more
doaj   +1 more source