Results 171 to 180 of about 8,132,244 (286)

Dynamical interactions among protocell populations: Implications for membrane-mediated chemical evolution. [PDF]

Philos Trans R Soc Lond B Biol Sci
Das S, Pal R, Rajamani S.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Editorial: Planetary nebulae as tools for astrophysics

Frontiers in Astronomy and Space Sciences, 2023
Miriam Peña, Karen B. Kwitter, Marcelo Miguel Miller Bertolami, Christophe Morisset, Michael Richer   +4 more
doaj   +1 more source

Chemical Evolution of Aplithianine Class of Serine/Threonine Kinase Inhibitors. [PDF]

J Med Chem
Du L, Wilson BAP, Moore WJ, Dalilian M, Shenoy SR, Li N, Martinez Fiesco JA, Hwang JY, Smith EA, Wamiru A, Goncharova EI, Alvarez de la Cruz A, Pagadala K, Piswa HK, Patteti V, Jampana VP, Manepalli P, Nimmala R, Marri NR, Gunuguntla M, Reddy JJ, Schneekloth JS, Zhang P, O'Keefe BR.   +23 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Chemical Information Bulletin

, 2019
Periodic supplement for "the regular journals of the American Chemical Society," containing annotated bibliographies of chemical documentation literature as well as information about meetings, conferences, awards, scholarships, and other news from the ...
American Chemical Society. Division of Chemical Information., Currano, Judith N.   +1 more
core  

Chemical Evolution of Early Macromolecules: From Prebiotic Oligopeptides to Self-Organizing Biosystems via Amyloid Formation. [PDF]

Chemistry
Bencs F, Taricska N, Dürvanger Z, Horváth D, Fazekas Z, Grolmusz V, Farkas V, Perczel A.   +7 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Chemical evolution of ASO-like DNAzymes for effective and extended gene silencing in cells. [PDF]

Nucleic Acids Res
Liu Y, Zhang S, Zhang M, Liu X, Wu Y, Wu Q, Chaput JC, Wang Y.   +7 more
europepmc   +1 more source

Tracking the Chemical Evolution of Iodine Species Using Recurrent Neural Networks. [PDF]

ACS Omega, 2020
Bilbrey JA, Marrero CO, Sassi M, Ritzmann AM, Henson NJ, Schram M.   +5 more
europepmc   +1 more source