Results 191 to 200 of about 389,444 (301)

Chemical Evolution of Biomass Burning Aerosols across Wildfire Plumes in the Western U.S.: From Near-Source to Regional Scales. [PDF]

ACS EST Air
Farley R, Zhou S, Collier S, Jiang W, Onasch TB, Shilling JE, Kleinman L, Sedlacek Iii AJ, Zhang Q.   +8 more
europepmc   +1 more source

A dual perspective on the microwave-assisted synthesis of HCN polymers towards the chemical evolution and design of functional materials. [PDF]

Sci Rep, 2020
Hortal L, Pérez-Fernández C, de la Fuente JL, Valles P, Mateo-Martí E, Ruiz-Bermejo M.   +5 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Chemical evolution characteristics and influencing factors of groundwater in the saline and fresh water funnel area in Hengshui City, North China. [PDF]

Sci Rep
Yu Y, Yan B, Tuo Y, Zhan X, Xie X.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Chemical evolution and the preservation of organic compounds on Mars

, 1989
Several lines of evidence suggest that the environment on early Mars and early Earth were very similar. Since life is abundant on Earth, it seems likely that conditions on early Earth were conducive to chemical evolution and the origin of life.
Kanavarioti, Anastassia, Mancinelli, Rocco L.   +1 more
core   +1 more source

Alkaline saline lakes: A chemical evolution experiment evaluating the stability of formaldehyde in an aqueous saline environment. [PDF]

Heliyon
Fuentes-Carreón CA, Meléndez-López AL, Cruz-Castañeda JA, Negrón-Mendoza A.   +3 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Chemical Evolution and Biological Evaluation of Natural Products for Efficient Therapy of Acute Lung Injury. [PDF]

Adv Sci (Weinh)
Fan C, Zhang Z, Lai Z, Yang Y, Li J, Liu L, Chen S, Hu X, Zhao H, Cui S.   +9 more
europepmc   +1 more source

Structural and chemical evolution of Au-silica core-shell nanoparticles during 20 keV helium ion irradiation: a comparison between experiment and simulation. [PDF]

Sci Rep, 2020
Mousley M, Möller W, Philipp P, Hlawacek G, Wirtz T, Eswara S.   +5 more
europepmc   +1 more source