Results 201 to 210 of about 1,572,221 (316)

The Chemical Evolution of Cool White Dwarfs and the Age of the Local Galactic Disk [PDF]

, 1997
P. Bergeron, M. T. Ruíz, S. K. Leggett
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Chemical Evolution of Early Macromolecules: From Prebiotic Oligopeptides to Self-Organizing Biosystems via Amyloid Formation. [PDF]

Chemistry
Bencs F, Taricska N, Dürvanger Z, Horváth D, Fazekas Z, Grolmusz V, Farkas V, Perczel A.   +7 more
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Chemical evolution of ASO-like DNAzymes for effective and extended gene silencing in cells. [PDF]

Nucleic Acids Res
Liu Y, Zhang S, Zhang M, Liu X, Wu Y, Wu Q, Chaput JC, Wang Y.   +7 more
europepmc   +1 more source

Tracking the Chemical Evolution of Iodine Species Using Recurrent Neural Networks. [PDF]

ACS Omega, 2020
Bilbrey JA, Marrero CO, Sassi M, Ritzmann AM, Henson NJ, Schram M.   +5 more
europepmc   +1 more source

Evolution and the chemical structure of the earth as inferred from isotopic ratios.

, 1989
Ichiro Kaneoka
openalex   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Chemical Evolution of Biomass Burning Aerosols across Wildfire Plumes in the Western U.S.: From Near-Source to Regional Scales. [PDF]

ACS EST Air
Farley R, Zhou S, Collier S, Jiang W, Onasch TB, Shilling JE, Kleinman L, Sedlacek Iii AJ, Zhang Q.   +8 more
europepmc   +1 more source

A dual perspective on the microwave-assisted synthesis of HCN polymers towards the chemical evolution and design of functional materials. [PDF]

Sci Rep, 2020
Hortal L, Pérez-Fernández C, de la Fuente JL, Valles P, Mateo-Martí E, Ruiz-Bermejo M.   +5 more
europepmc   +1 more source