Results 201 to 210 of about 367,412 (259)

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Lyapunov Thermodynamic Stability of the Evolution of Conservatively Perturbed Chemical Equilibrium. [PDF]

Entropy (Basel)
Bhalekar AA, Tangde VM, Andresen B.
europepmc   +1 more source

Universal progression of structure and dynamics in colloidal nanocrystal gels during salt-accelerated aging. [PDF]

Sci Adv
Ofosu CK, Brackett WD, Conrad DL, Qian D, Lee TL, Kang J, Choi J, Bessmertnaya A, Oberlander JD, Green AM, Lehmkühler F, Fluerasu A, Narayanan S, Zhang Q, Chu M, Anslyn EV, Truskett TM, Milliron DJ.   +17 more
europepmc   +1 more source

Spatially directed charge transfer in a polymer framework for efficient photocatalytic overall water splitting. [PDF]

Chem Sci
Meng XY, Li JJ, Liu P, Wang T, Pan M, Ching CC, Men YL, Chen X, Zhou YN, Pan YX.   +9 more
europepmc   +1 more source

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Chemical Evolution

1997
Even if we take a ‘replicators first’ view of the origin of life, we still have to explain how a chemical environment arose that was sufficiently diverse for such replicators to be formed. As a minimum, we must explain the abiotic formation of sugars and amino acids, and of nucleotides or of some simpler molecules capable of base pairing, and hence of ...
John Maynard Smith, Eors Szathmary
openaire   +1 more source

Evolution was Chemically Constrained

Journal of Theoretical Biology, 2003
The objective of this paper is to present a systems view of the major features of biological evolution based upon changes in internal chemistry and uses of cellular space, both of which it will be stated were dependent on the changing chemical environment.
R J P, Williams, J J R, Fraústo Da Silva   +1 more
openaire   +2 more sources