Results 221 to 230 of about 7,604,095 (315)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Alkaline saline lakes: A chemical evolution experiment evaluating the stability of formaldehyde in an aqueous saline environment. [PDF]

Heliyon
Fuentes-Carreón CA, Meléndez-López AL, Cruz-Castañeda JA, Negrón-Mendoza A.   +3 more
europepmc   +1 more source

Structural and chemical evolution of Au-silica core-shell nanoparticles during 20 keV helium ion irradiation: a comparison between experiment and simulation. [PDF]

Sci Rep, 2020
Mousley M, Möller W, Philipp P, Hlawacek G, Wirtz T, Eswara S.   +5 more
europepmc   +1 more source

The Primordial Helium Abundance as Determined from Chemical Evolution of Irregular Galaxies

, 1993
M. J. Balbes, R. N. Boyd, Grant J. Mathews   +2 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Chemical Evolution and Biological Evaluation of Natural Products for Efficient Therapy of Acute Lung Injury. [PDF]

Adv Sci (Weinh)
Fan C, Zhang Z, Lai Z, Yang Y, Li J, Liu L, Chen S, Hu X, Zhao H, Cui S.   +9 more
europepmc   +1 more source

Inhomogeneous chemical evolution of the Galactic disk

, 1993
G. Malinie, D. H. Hartmann, Donald D. Clayton, Grant J. Mathews   +3 more
openalex   +1 more source

Thresholds on star formation and the chemical evolution of galactic discs: cosmochronology and the age of the Galaxy [PDF]

, 1996
Khalil Chamcham, M. Hendry
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Editorial: Planetary nebulae as tools for astrophysics

Frontiers in Astronomy and Space Sciences, 2023
Miriam Peña, Karen B. Kwitter, Marcelo Miguel Miller Bertolami, Christophe Morisset, Michael Richer   +4 more
doaj   +1 more source