Results 71 to 80 of about 367,412 (259)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

EURAD State-of-the-Art Report: ACED assessment of the chemical evolution at the disposal cell scale—part I—processes at interfaces and evolution at disposal cell scale

Frontiers in Nuclear Engineering
Within the framework of the European Joint Programme on Radioactive Waste Management, the work package ACED–Assessment of chemical evolution of intermediate level (ILW) and high level (HLW) waste at disposal cell scale–used combined experimental and ...
Erika Neeft, Guido Deissmann, Diederik Jacques   +2 more
doaj   +1 more source

Is Life an Unavoidable Consequence of the Formation of the Universe? Investigating the Formation of Bio-Precursors and the Signature of Earth-Like Living Forms

Frontiers in Astronomy and Space Sciences, 2018
This contribution to the Research Topic “Imagining the Future of Astronomy and Space Sciences” focuses on astrobiology and exoplanetary research. Understanding the origin of life is the main scientific challenge to this century and an interdisciplinary ...
Ana I. Gomez de Castro
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

EURAD State-of-the-Art Report: Assessment of the chemical evolution at the disposal cell scale – part II – gaining insights into the geochemical evolution

Frontiers in Nuclear Engineering
Long time frames are to be considered in the safety and performance assessment of deep geological disposal of intermediate and high level radioactive waste.
Guido Deissmann, Erika Neeft, Diederik Jacques   +2 more
doaj   +1 more source

Chemical Evolution Reimagined

, 2022
Some of the most interesting open questions about the origins of life and molecular sciences center on chemical evolution and the spontaneous generation of new complex and functional chemical species. The spectacular polymers that underlay biology demonstrate an untapped, by modern science, creative potential.
Moran Frenkel Pinter, Kavita Matange, Vahab Rajaei, John T Costner, Adelaide Robertson, Jennifer Seoyoung Kim, Anton S Petrov, Jessica C. Bowman, Loren Dean Williams   +8 more
openaire   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Galactic Chemical Evolution

, 2016
We analyze the evolution of oxygen abundance radial gradients resulting from our chemical evolution models calculated with different prescriptions for the star formation rate (SFR) and for the gas infall rate, in order to assess their respective roles in shaping gradients.
Gibson, Brad K., Cavichia, Oscar, Costa, Roberto Dell’Aglio Dias da, Díaz, Ángeles I., Mollá, Mercedes   +4 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source