Results 61 to 70 of about 389,444 (301)
Advancements in galactic chemical evolution
, 2022 In this thesis we examine several improvements which can be made to the canonical under- standing of Galactic Chemical Evolution (GCE) models in light of modern developments in stellar physics and new modelling techniques.
Fraser-Govil, Jack
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Chemical evolution of methanogenic reactors (n = 6).
, 2014 Chemical evolution of methanogenic reactors (n = 6).
Jessica Radford (636473) +6 more
core +1 more source
Complex and Messy Prebiotic Chemistry: Obstacles and Opportunities for an RNA World
LifeTraditional prebiotic chemistry experiments often isolated single reactions under clean, controlled conditions, yet early Earth was chemically diverse and physically dynamic.
Alberto Vázquez-Salazar
doaj +1 more source
Life, 2022 The role of minerals in the chemical evolution of RNA molecules is an important issue when considering the early stage of the Hadean Earth. In particular, the interaction between functional ribozymes and ancient minerals under simulated primitive ...
Kunio Kawamura +5 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A plausible pathway to prebiotic peptides via amino acid amides on the primordial Earth
Earth and Planetary PhysicsThe prebiotic synthesis of peptides prior to ribosome-catalyzed processes remains an enigma. The synthesis of abiotic peptides from amino acids (AAs) is primarily constrained by high activation energies and unfavorable thermodynamics, necessitating the ...
DingWei Gan +8 more
doaj +1 more source
Looking for the origin of life in cosmochemistry: Asteroids and their carbon-rich meteorites
Mètode Science Studies Journal: Annual Review, 2016 Carbonaceous chondrite meteorites are carbon-containing fragments of primitive asteroids that have offered the only samples available to date giving insights into chemical evolution in laboratory analyses.
Sandra Pizzarello
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Toy trains, loaded dice and the origin of life: dimerization on mineral surfaces under periodic drive with Gaussian inputs [PDF]
Royal Society Open Science, 2017 In a major extension of previous work, we model the putative hydrothermal rock pore setting for the origin of life on Earth as a series of coupled continuous flow units (the toy train).
Rowena Ball, John Brindley
doaj +1 more source