Results 41 to 50 of about 1,649,548 (237)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

`Pure' Supernovae and Accelerated Expansion of the Universe

, 2011
A special class of type Ia supernovae that is not subject to ordinary and additional intragalactic gray absorption and chemical evolution has been identified.
A. Aguirre, A. Aguirre, A. G. Riess, A. G. Riess, B. Bassett, B. W. Holwerda, D. Yu. Tsvetkov, D. Yu. Tsvetkov, E. Mortsell, E. S. Gorbovskoy, G. Paturel, H. Lampeitl, I. Iben Jr., J. Guy, J. Whelan, M. Hicken, M. Kowalski, M. Sullivan, M. Sullivan, M. V. Pruzhinskaya, R. Barbon, R. Webbink, S. Perlmutter, V. M. Lipunov, V. M. Lipunov, Yu. P. Pskovskii, Yu. P. Pskovskii   +26 more
core   +1 more source

Natural selection in chemical evolution [PDF]

Journal of Theoretical Biology, 2007
We propose that chemical evolution can take place by natural selection if a geophysical process is capable of heterotrophic formation of liposomes that grow at some base rate, divide by external agitation, and are subject to stochastic chemical avalanches, in the absence of nucleotides or any monomers capable of modular heredity.
Fernando, Chrisantha, Rowe, Jonathan
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The building up of the disk galaxy M33 and the evolution of the metallicity gradient

, 2007
The evolution of radial gradients of metallicity in disk galaxies and its relation with the disk formation are not well understood. Theoretical models of galactic chemical evolution make contrasting predictions about the time evolution of metallicity ...
Aller, Arnett, Aubert, Beaulieu, Block, Block, Brooks, Bullock, Chabrier, Chang, Chiappini, Chiappini, Chiappini, Chieffi, Ciardullo, Ciardullo, Corbelli, Corbelli, Crockett, D. Galli, Davidge, de Boer, Devereux, Diaz, E. Corbelli, Elmegreen, Engargiola, Ferrini, Ferrini, Ferrini, Ferrini, Freedman, Freeman, Friel, Gallagher, Galletti, Garnett, Gavilán, Goetz, Henry, Henry, Henry, Herrero, Herwig, Heyer, Hippelein, Hirschi, Holmberg, Hoopes, Hou, Israel, Kennicutt, Kennicutt, Kennicutt, Keres, Kim, Koeppen, Kroupa, Kroupa, Kwitter, L. Magrini, Maciel, Maciel, Maciel, Maciel, Magrini, Magrini, Magrini, Marigo, McCarthy, McConnachie, Mollà, Mollà, Mollà, Monteverde, Monteverde, Naab, Newton, Portinari, Portinari, Regan, Richer, Romano, Rowe, Salpeter, Sandage, Scalo, Scalo, Smith, Stanghellini, Stephens, Talbot, Thielemann, Tiede, Tinsley, Tosi, Urbaneja, Venn, Vílchez, Wakker, Westmeier, Willner, Woosley, Wyse, Young   +104 more
core   +1 more source

On the Galactic chemical evolution of sulfur [PDF]

Astronomy & Astrophysics, 2004
Accepted by A&A, 12 pages.
Ryde, N., Lambert, D. L.
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Period and chemical evolution of SC stars

, 2004
The SC and CS stars are thermal-pulsing AGB stars with C/O ratio close to unity. Within this small group, the Mira variable BH Cru recently evolved from spectral type SC (showing ZrO bands) to CS (showing weak C2).
Aaron Price, Abia, Albert A. Zijlstra, Alksne, Anders, Andrew J. Markwick, Andrew P. Jacob, Bateson, Bedding, Bedding, Bedding, Bedding, Broens, Cameron, Catchpole, Chase, Clegg, Ferrarotti, Foster, Fox, Gill, Greaves, Greene, Groenewegen, Gál, Haniff, Hawkins, Hazen, Hony, Janet A. Mattei, Jorissen, Keenan, Keenan, Keller, Kiss, Kiss, Kristen D. Alexander, Kurochkin, Lloyd, Lloyd Evans, Loidl, László L. Kiss, Mattei, Mattei, Mikako Matsuura, Mowlavi, Percy, Reyniers, Rita Loidl-Gautschy, Sanford, Sharp, Stephenson, Szatmáry, Tarafdar, Templeton, Thome, Timothy R. Bedding, Tsuji, van Belle, Vassiliadis, Vello Tabur, Walker, Walker, Walker, Welch, White, Whitelock, Whitelock, Wood, Wood, Wood, Wood, Wyckoff, Wyckoff, Zemansky, Zijlstra, Zijlstra, Zijlstra   +77 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Chemical Evolution in the Carina Dwarf Spheroidal

, 2004
We present metallicities for 487 red giants in the Carina dwarf spheroidal (dSph) galaxy that were obtained from FLAMES low-resolution Ca triplet (CaT) spectroscopy. We find a mean [Fe/H] of -1.91 dex with an intrinsic dispersion of 0.25 dex, whereas the
Evans, N. W., Gilmore, G. F., Grebel, E. K., Harbeck, D., Kleyna, J. T., Koch, A., Wilkinson, M. I., Wyse, R. F. G.   +7 more
core   +1 more source