Results 71 to 80 of about 389,444 (301)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

EURAD State-of-the-Art Report: ACED assessment of the chemical evolution at the disposal cell scale—part I—processes at interfaces and evolution at disposal cell scale

Frontiers in Nuclear Engineering
Within the framework of the European Joint Programme on Radioactive Waste Management, the work package ACED–Assessment of chemical evolution of intermediate level (ILW) and high level (HLW) waste at disposal cell scale–used combined experimental and ...
Erika Neeft, Guido Deissmann, Diederik Jacques   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Chemical evolution of dSph galaxy Sextans

, 2020
VizieR online Data Catalogue associated with article published in journal Astronomy & Astrophysics with title 'The chemical evolution of the dwarf spheroidal galaxy Sextans.' (bibcode: 2020A&A...642A ...
Laboratoire Lagrange, Université de Nice Sophia-Antipolis, Observatoire de la Côte d'Azur, Instituto de Astrofísica de Canarias, University of Victoria, Venn, K., Physics Institute, Tolstoy, Eline, University of Cambridge, Shetrone, M., Lucchesi, R., Battaglia, G., Jablonka, P., Theler, R., Primas, F., Helmi, Amina, Instituto de Astrofísica de Canarias (IAC), European Southern Observatory, Université de Nice Sophia Antipolis, North, P., Irwin, M., University of Texas at Austin, Lardo, C., Hill, V., Departamento de Astrofísica, Universidad de la Laguna, GEPI, Observatoire de Paris, Université PSL, CNRS, Kaufer, A., Astronomy   +25 more
core   +1 more source

EURAD State-of-the-Art Report: Assessment of the chemical evolution at the disposal cell scale – part II – gaining insights into the geochemical evolution

Frontiers in Nuclear Engineering
Long time frames are to be considered in the safety and performance assessment of deep geological disposal of intermediate and high level radioactive waste.
Guido Deissmann, Erika Neeft, Diederik Jacques   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Necessary Condition for Coexistence of Autocatalytic Replicators in a Prebiotic Environment

Life, 2013
A necessary, but not sufficient, mathematical condition for the coexistence of short replicating species is presented here. The mathematical condition is obtained for a prebiotic environment, simulated as a fed-batch reactor, which combines monomer ...
Martha A. Grover, Andres F. Hernandez
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Quantifying the uncertainties of chemical evolution studies

, 2005
Stellar lifetimes and initial mass function are basic ingredients of chemical evolution models, for which different recipes can be found in the literature.
F. Matteucci, C. Chiappini, M. Tosi, D. Romano   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source