Results 111 to 120 of about 255,270 (305)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cryogenic fractionation as a post-fermentation strategy for partial dealcoholisation of red wine: impacts on acid balance, colour, and phenolics

OENO One
A rise in popularity of no/low-alcohol beverages and increasing vineyard temperatures associated with climate change has driven research into and the subsequent improvement of dealcoholisation methods.
George Coles, Akshay Baboo, James Clapham   +2 more
doaj   +1 more source

Mapping Observations of DNC and HN^13C in Dark Cloud Cores

, 2003
We present results of mapping observations of the DNC, HN^13C, and H^13CO^+ lines (J=1-0) toward 4 nearby dark cloud cores, TMC-1, L1512, L1544, and L63, along with observations of the DNC and HN^13C lines (J=2-1) toward selected positions.
Gerin M., Guelin M., Hirahara Y., Howe D. A., Howe D. A., Masafumi Ikeda, Roberts H., Satoshi Yamamoto, Tomoya Hirota, Ward-Thompson D.   +9 more
core   +2 more sources

Probing Mechanical and Chemical Instabilities in Neutron-Rich Matter [PDF]

, 2001
The isospin-dependence of mechanical and chemical instabilities is investigated within a thermal and nuclear transport model using a Skyrme-type phenomenological equation of state for neutron-rich matter.
Akmal, Akmal, Alkahzov, Andrew T. Sustich, Bao-An Li, Baran, Baran, Barranco, Bauer, Bin Zhang, Bombaci, Bombaci, Brown, Catalano, Colonna, Di Toro, Ghetti, Ghetti, Hansen, Heiselberg, Horowitz, Huber, Huber, Jaqaman, Lattimer, Lattimer, Lattimer, Lee, Li, Li, Li, Li, Li, Matt Tilley, Moretto, Mueller, Müller, Nazarewicz, Oyamatsu, Pan, Prakash, Shlomo, Sumiyoshi, Sumiyoshi, Tanihata, Tsang, Westfall, Wiringa, Xu, Yennello   +49 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Polyurethane Coatings Based on Chemically Unmodified Fractionated Lignin

ACS Sustainable Chemistry & Engineering, 2015
New lignin-based thermoset polyurethane (PU) coatings with high lignin content are presented in this work. These materials were obtained by extracting a sol fraction from a raw kraft lignin sample with the bioderived solvent 2-methyltetrahydrofuran (MeTHF), and subsequently directly cross-linking the MeTHF-soluble lignin fraction with a toluene ...
GRIFFINI, GIANMARCO ENRICO, Passoni, Valeria, SURIANO, RAFFAELLA, LEVI, MARINELLA, TURRI, STEFANO   +4 more
openaire   +1 more source

Deuterium fractionation in the Horsehead edge [PDF]

, 2006
Deuterium fractionation is known to enhance the [DCO+]/[HCO+] abundance ratio over the D/H elemental ratio of about 1e-5 in the cold and dense gas typically found in pre-stellar cores.
Abergel, Brown, Caselli, Cernicharo, D. Teyssier, Flower, Flower, Gerlich, Goicoechea, Guelin, Guilloteau, Habart, Hatchell, Hily-Blant, J. Pety, J. R. Goicoechea, Le Bourlot, Le Petit, Leurini, Linsky, M. Gerin, Milam, P. Hily-Blant, Penzias, Pety, Philipp, Roberts, Roberts, Roueff, Smith, Solomon, Turner, van Dishoeck, Walmsley, Ward-Thompson, Watson   +35 more
core   +5 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Evaluating the Protein Value of Fresh Tropical Forage Grasses and Forage Legumes Using In Vitro and Chemical Fractionation Methods. [PDF]

Animals (Basel), 2021
Salazar-Cubillas KC, Dickhoefer U.
europepmc   +1 more source

Possible isotopic fractionation effects in sputtered minerals [PDF]

A model which makes definite predictions for the fractionation of isotopes in sputtered material is discussed. The fractionation patterns are nonlinear, and the pattern for a particular set of isotopes depends on the chemical matrix within which those ...
Haff, P. K., Tombrello, T. A., Watson, C. C.   +2 more
core   +1 more source