Results 111 to 120 of about 5,463,250 (252)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Development of an innovative methodology combining chemical fractionation and in vivo analysis to investigate the biological properties of cheese. [PDF]

PLoS One, 2020
Cardin G, Ripoche I, Poupet C, Bonnet M, Veisseire P, Chalard P, Chauder A, Saunier E, Priam J, Bornes S, Rios L.   +10 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Obtenção e separação de compostos bioativos de schinus terebinthifolius raddi em meio supercrítico e avaliação da atividade citotóxica em células leucêmicas [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2013A utilização de fluido supercrítico para fracionamento e purificação de misturas complexas tem sido cada ...
Livia, Mayra Arauco
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Towards low energy greywater treatment of surfactants and pathogens

Discover Water
Greywater reuse in households and off-grid applications is growing in response to water scarcity. Effective treatment technologies must balance water quality, efficiency, and low energy or chemical inputs. This study presents a low-energy, non-biological
Zachary Bogart, Aksana Atrashkevich, Jirapat Ananpattarachai, Shahnawaz Sinha, Sergi Garcia-Segura, Paul Westerhoff   +5 more
doaj   +1 more source

Dissolved organic matter mediates the interactions between bacterial community and heavy metal fractionation in contaminated coal mine soils

Ecotoxicology and Environmental Safety
Heavy metal (HM) contamination in coal mine soils disrupts local bacterial networks, leading to prolonged soil deterioration. Dissolved organic matter (DOM), a crucial soil component, actively modulates both bacterial metabolism and HM mobilization ...
Wei Lin, Xiaolong Guo, Yili Wang, Junlin Zhao, Xiang Cheng, Yingjie Li, Chunyang Zhou   +6 more
doaj   +1 more source

Chemical Literature

, 1969
Quarterly supplement for "the regular journals of the American Chemical Society," containing annotated bibliographies of chemical documentation literature as well as information about meetings, conferences, awards, scholarships, and other news from the ...
American Chemical Society. Division of Chemical Literature.
core  

Integration methods for enhanced trapping and spectroscopy in optofluidics [PDF]

, 2012
“Lab on a Chip” technologies have revolutionized the field of bio-chemical analytics. The crucial role of optical techniques in this revolution resulted in the emergence of a field by itself, which is popularly termed as “optofluidics”.
Ashok, Praveen Cheriyan
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source