Results 121 to 130 of about 255,270 (305)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Comparative study on Fractional Isothermal Chemical Model

Alexandria Engineering Journal, 2021
This article investigates a family of approximate solutions for the fractional isothermal chemical (FIC) equation based on mass action kinetics for autocatalytic feedback, involving the conversion of a reactant in the Liouville-Caputo sense. We apply two methods to construct numerical solutions of the FIC equation.
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Contrasting properties of soil organic matter fractions isolated by different physical separation methodologies

Geoderma
Physical soil organic matter (SOM) fractions provide increased insight into the biogeochemical functioning of soils. Several fractionation methodologies have been developed to separate particulate (POM) from mineral-associated organic matter (MAOM ...
S. Leuthold, J.M. Lavallee, M.L. Haddix, M.F. Cotrufo   +3 more
doaj   +1 more source

Chemical Fractionation Joint to In-Mixture NMR Analysis for Avoiding the Hepatotoxicity of Teucrium chamaedrys L. subsp. chamaedrys. [PDF]

Biomolecules, 2021
Piccolella S, Scognamiglio M, D'Abrosca B, Esposito A, Fiorentino A, Pacifico S.   +5 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Ultra-violet absorption cross sections of isotopically substituted nitrous oxide species: ¹⁴N¹⁴NO, ¹⁵N¹⁴NO, ¹⁴N¹⁵NO and ¹⁵N¹⁵NO [PDF]

Atmospheric Chemistry and Physics, 2004
The isotopically substituted nitrous oxide species 14N14NO, 15N14NO, 14N15NO and 15N15NO were investigated by ultra-violet (UV) absorption spectroscopy. High precision cross sections were obtained for the wavelength range 181 to 218nm at temperatures of ...
P. von Hessberg, J. Kaiser, J. Kaiser, M. B. Enghoff, C. A. McLinden, S. L. Sorensen, T. Röckmann, M. S. Johnson   +7 more
doaj  

Chemical Fractionation, Environmental, and Human Health Risk Assessment of Potentially Toxic Elements in Soil of Industrialised Urban Areas in Serbia. [PDF]

Int J Environ Res Public Health, 2021
Pavlović D, Pavlović M, Perović V, Mataruga Z, Čakmak D, Mitrović M, Pavlović P.   +6 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Carbon isotope fractionation and depletion in TMC1

, 2012
12C/13C isotopologue abundance anomalies have long been predicted for gas-phase chemistry in molecules other than CO and have recently been observed in the Taurus molecular cloud in several species hosting more than one carbon atom, i.e.
Adande, Balser, Bensch, Boger, Burgh, Cambrésy, Flower, Furuya, Gerin, Goldsmith, H. S. Liszt, L. M. Ziurys, Lis, Liszt, Lucas, Maezawa, Milam, Ohishi, Pineda, Pratap, Sakai, Sheffer, Smith, Sonnentrucker, Takano, Wakelam, Willacy, Wilson, Wilson, Wolfire, Woods   +30 more
core   +1 more source