Results 121 to 130 of about 109,469 (312)
Potassium isotope fractionation during chemical weathering of basalts
, 2020 Non-traditional stable isotopes (e.g., Li, Mg, and Si) are increasingly used as tracers for studying Earth's surface processes. The isotopes of potassium (K), a highly soluble and mobile element during weathering, could be a promising new tracer for ...
Chen, H., Wang, K., Liu, X.-M.
core +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Chemical Timescale of Dark Cloud Cores Estimated from Deuterium Fractionation
, 2002 The chemical evolutionary age of dark cloud cores is estimated from the degree of deuterium fractionation, on the assumption that the chemical model used is reasonable.
HERBST, Eric +6 more
core +1 more source
Literature review of physical and chemical pretreatment processes for lignocellulosic biomass
, 2010 Different pretreatment technologies published in public literature are described in terms of the mechanisms involved, advantages and disadvantages, and economic assessment.
Huijgen, W. +3 more
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Cadmium accumulation, subcellular distribution and chemical fractionation in hydroponically grown Sesuvium portulacastrum [Aizoaceae]. [PDF]
PLoS One, 2020 Uddin MM, Chen Z, Huang L.
europepmc +1 more source
Modeling the signature of sulfur mass-independent fractionation produced in the Archean atmosphere
, 2014 Minor sulfur isotope anomalies indicate the absence of O2 from the Archean atmosphere. A rich dataset showing large variations in magnitude and sign of Δ33S and Δ36S, preserved in both sulfates and sulfides, suggests that further constraints on Archean ...
Claire, Mark +10 more
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source