Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Ambient ozone pollution at a coal chemical industry city in the border of Loess Plateau and Mu Us Desert: characteristics, sensitivity analysis and control strategies. [PDF]
PeerJ, 2021 Yin M +6 more
europepmc +1 more source
Couleurs à la mode. Impressionism as an Effect of the Chemical Industry
, 2015 Wolf Kittler
openalex +1 more source
Peter J. Morris and Colin A. Russell, Archives of the British chemical industry 1750–1914: a handlist, contr. ed. John Graham Smith, BSHS Monograph 6, Faringdon, British Society for the History of Science, 1988, 8vo, pp. xi, 273, £14.50/$31.00 (BSHS members £9.00/$19.00), (paperback). Available from the Executive Secretary, BSHS, 31 High St.,Stanford in the Vale, Faringdon, Oxon. SN7 8LH. [PDF]
, 1990 Julia Sheppard
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
International Journal of Chemical EngineeringA comprehensive model for the product property prediction based on coupling polymerization kinetics, product property model, and continuously stirred tank reactor model was established to simulate a two-stage industrial ethylene-propylene ...
Hu Li +3 more
doaj +1 more source
Renewable hydrogen for the chemical industry. [PDF]
MRS Energy Sustain, 2020 Rambhujun N +7 more
europepmc +1 more source
Physio-chemical Parameters of Wastewater from Food Industries of Faisalabad
, 2020 Muhammad Naveed +7 more
openalex +1 more source