Results 111 to 120 of about 9,039,490 (311)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Wastewater Treatments for the Food Industry: Physical-Chemical Systems
, 2018 This chapter provides a general overview of physical-chemical wastewater remediation systems in the food industry. Water reuse systems are becoming more and more interesting and promising technologies, depending on merely quantitative estimations ...
Barbera Marcella, Gurnari Giovanni
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Journal of IsotopesBoron Neutron Capture Therapy (BNCT) is a binary targeted radiotherapeutic approach that achieves single-cell-level tumor eradication via the 10B(n,α)7Li nuclear reaction，thereby offering distinct clinical advantages for recurrent and refractory solid ...
Gaosheng WU +5 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Science-an important lever to tackle sustainability in the specialty chemical industry. [PDF]
Natl Sci Rev, 2023 Zhou WJ, Metivier P.
europepmc +1 more source
Applications Of Microspectroscopy, Hyperspectral Chemical Imaging And Fluorescence Microscopy In Chemistry, Biochemistry, Biotechnology, Molecular And Cell Biology [PDF]
, 2011 Chemical imaging is a technique for the simultaneous measurement of spectra (chemical information) and images or pictures (spatial information)^1,2^. The technique is most often applied to either solid or gel samples, and has applications in chemistry ...
I. C. Baianu
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Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Biotechnology applications in the chemical industry
, 2002 'BIO-WISE is a major UK government programme funded by the Department of Trade and Industry' - Inside front cover. Title from coverAvailable from British Library Document Supply Centre- DSC:m03/10386 / BLDSC - British Library Document Supply ...
Great Britain. Department of Trade and Industry (United Kingdom) +1 more
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