Results 121 to 130 of about 8,448,076 (261)

Survey of Instrumentation Use in Industry: What Does Industry Want New Chemists to Know?

open access: yes
Instrumentation plays a vital role in almost every area of chemistry. As such, it is imperative that the undergraduate curriculum is designed to allow students to have opportunities to use a variety of instruments to best prepare them for careers in ...
Atkinson, Molly B   +2 more
core   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

open access: yesMolecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

The development of chemical technologies in Ukraine and abroad

open access: yes, 2014
Composite materials, coating ceramic, polycrystalline silicon, nanomembranes and many others new items will allow the chemical industry to start producing a fundamentally different products with previously unimaginable properties. Композиційні матеріали,
Zaets, Kristina   +2 more
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

The Application of Digital Factory in domestic chemical industry

open access: yes, 2015
The business competition among chemical companies is more and more fiercely with the development of the society. The output, cost, quality of the industrial products are attracting more attention.
邹涛, Ou, Hejian
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Elasticity-gated thermal plasticity via superheating-mediated nucleation and growth in polymer networks

open access: yesNature Communications
Living systems encode environmental history into material structure, enabling adaptive response thresholds, a capability lacking in synthetic materials with fixed thermal transitions.
Guye Wei   +4 more
doaj   +1 more source

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