Results 41 to 50 of about 1,579,641 (309)

Chemical industry supply chain optimisation using agent-based modelling [PDF]

, 2013
In this paper we present an application of Supply Chain Spread Sheet Simulator (SCSS) in a task dealing with chemical industry supply chain redesign and optimisation.
Dyntar, Jakub, Škvor, Jan
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Polymer-Supported Raney Nickel Catalysts for Sustainable Reduction Reactions

Molecules, 2016
Green is the future of chemistry. Catalysts with high selectivity are the key to green chemistry. Polymer-supported Raney catalysts have been found to have outstanding performance in the clean preparation of some chemicals.
Haibin Jiang, Shuliang Lu, Xiaohong Zhang, Wei Dai, Jinliang Qiao   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Isolation of Sulfuretin and Butin from Rhus verniciflua Stokes Using Medium-pressure Liquid Chromatography and their Tyrosinase Inhibitory Effects

BioResources, 2015
The aim of this study was to separate antityrosinase compounds of the ethyl acetate fraction from Rhus verniciflua Stokes using medium pressure liquid chromatography.
Hongxia Chen, Chengzhang Wang, Jianzhong Ye, Hao Zhou, Ran Tao   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Synthesis of Spherical Silver-coated Li4Ti5O12 Anode Material by a Sol-Gel-assisted Hydrothermal Method

Nanoscale Research Letters, 2017
ᅟ Ag-coated spherical Li4Ti5O12 composite was successfully synthesized via a sol-gel-assisted hydrothermal method using an ethylene glycol and silver nitrate mixture as the precursor, and the influence of the Ag coating contents on the electrochemical ...
Jun Li, Si Huang, Shuaijun Xu, Lifang Lan, Lu Lu, Shaofang Li   +5 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Activating Progressive Sn2+ Nucleation by Micellar Structure Electrolyte for Dead-Sn-Free Aqueous Batteries

Nano-Micro Letters
Highlights Nanoscale spatial confinement of Sn2+ ions is realized in SnSO4 electrolyte by strategically dictating spontaneous assembly of nanomicelles with amphipathic sulfolane.
Xiaojia Lan, Zhaoyu Zhang, Yuekai Lin, Wencheng Du, Yufei Zhang, Minghui Ye, Zhipeng Wen, Yongchao Tang, Xiaoqing Liu, Cheng Chao Li   +9 more
doaj   +1 more source

Preparation and Characterization of Urushiol Methylene Acetal Derivatives with Various Degrees of Unsaturation in Alkyl Side Chain

International Journal of Polymer Science, 2015
Preparation of urushiol derivatives was carried out in response to the drug industry’s increasing demand for new synthetic anticancer agents. Urushiol methylene acetal derivatives were synthesized in high yields by reaction of urushiol with methylene ...
Chengzhang Wang, Yuanfeng He, Hao Zhou, Ran Tao, Hongxia Chen, Jianzhong Ye, Yusi Zhang   +6 more
doaj   +1 more source